SUPT5H and CCNT2

Number of citations of the paper that reports this interaction (PMID 15201869)
87

Data Source:
BioGRID (enzymatic study)

		SUPT5H	CCNT2
Gene Name		suppressor of Ty 5 homolog (S. cerevisiae)	cyclin T2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Cell Cycle Response To Organic Substance Gene Expression Viral Process Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Division
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat mRNA Capping HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Loss of Function of TGFBR2 in Cancer RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CSNK2A1 DBN1 DCAF6 GTF3C1 H2AFX HTATSF1 IK IKBKG LMAN2 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUPT4H1 TERF1 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B	6 interactors: BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H
Entrez ID		6829	905
HPRD ID		03655	04839
Ensembl ID		ENSG00000196235	ENSG00000082258
Uniprot IDs		O00267	B4DH21 O60583
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U	2IVX
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Cellular Macromolecule Biosynthetic Process Regulation Of Viral Transcription Macromolecule Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription From RNA Polymerase II Promoter Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Metabolic Process Cell Cycle Cellular Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Negative Regulation Of Gene Expression, Epigenetic Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cell Cycle Viral Process Chromatin Modification RNA Metabolic Process Chromatin Remodeling Gene Expression Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Replication Fork Arrest Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Difference) ?		19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Intersection) ?