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SUPT5H and SNX4
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
SUPT5H
SNX4
Description
SPT5 homolog, DSIF elongation factor subunit
sorting nexin 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DSIF Complex
Cytoplasm
Endosome
Early Endosome
Cytoplasmic Dynein Complex
Plasma Membrane
Membrane
SNARE Complex
Early Endosome Membrane
Protein-containing Complex
Presynaptic Endosome
Molecular Function
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Heterodimerization Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Protein Binding
Lipid Binding
Phosphatidylinositol-3-phosphate Binding
Phosphatidylinositol Binding
Transferrin Receptor Binding
Leptin Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription Elongation
Regulation Of Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Macroautophagy
Regulation Of DNA-templated Transcription Elongation
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Transport
Endocytic Recycling
Positive Regulation Of Histamine Secretion By Mast Cell
Positive Regulation Of Autophagosome Assembly
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
RNA Polymerase II Transcription Elongation
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Adult body size (
32376654
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Major depressive disorder x sex interaction (
34099189
)
Urate levels (
31578528
)
Interacting Genes
51 interacting genes:
C9orf78
CCNH
CCNT2
CDK7
CDK9
CEP55
CPSF7
CSNK2A1
DBN1
DCAF6
DSCAM
EXOSC7
FHL3
GOLGA2
GTF3C1
H2AX
HSPB1
HTATSF1
IK
IKBKG
LMAN2
MAD1L1
MAML3
MNAT1
PCBD1
PGK1
PHYHIP
PIN1
PNO1
POLR2A
PPIA
PPP2R2D
PRMT1
PRMT5
RPL9
SAP30BP
SIK1
SNRNP48
SNX4
SSBP3
SUMO2
SUPT4H1
TERF1
TEX11
TLE5
XRCC5
YBX2
ZBTB3
ZFYVE9
ZNF496
ZNF512B
18 interacting genes:
AGK
ARL6IP1
ATP6V0A1
BIN1
DGAT2L6
EGFR
HIVEP1
INSR
LEPR
MAGEA6
OGT
PDGFRA
PDGFRB
PTPN5
SH3GLB1
SNX2
SNX6
SUPT5H
Entrez ID
6829
8723
HPRD ID
03655
09334
Ensembl ID
ENSG00000196235
ENSG00000114520
Uniprot IDs
O00267
O95219
PDB IDs
2DO3
2E6Z
2E70
3H7H
4L1U
5OHO
5OHQ
5OIK
5U98
6EQY
6ER0
6GMH
6GML
6TED
7OKX
7OKY
7OL0
7PKS
7UNC
7UND
7YCX
8A3Y
8P4C
8P4D
8P4E
8P4F
8RBX
8UHA
8UHD
8UHG
8UI0
8UIS
8W8E
8W8F
9EGX
9EGY
9EGZ
9EH0
9EH2
9J0N
9J0O
9J0P
Enriched GO Terms of Interacting Partners
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Nucleus
Nucleic Acid Metabolic Process
Transcription Factor TFIIK Complex
CAK-ERCC2 Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
DNA-templated Transcription Initiation
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Gene Expression
Transcription Elongation By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription Elongation
Protein Peptidyl-prolyl Isomerization
Chromosome
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Chromosome Segregation
DNA Metabolic Process
Recombinational Repair
Protein Localization To Site Of Double-strand Break
Protein Binding
DNA Recombination
Transcription Pausing By RNA Polymerase II
Postsynaptic Cytosol
Histone H4R3 Methyltransferase Activity
Peptidyl-arginine Methylation
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Anoikis
Regulation Of Transcription Elongation By RNA Polymerase II
Transcription Elongation-coupled Chromatin Remodeling
Macromolecule Biosynthetic Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Autophagy
Receptor Complex
Phospholipase C Activator Activity
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Metanephric Glomerular Capillary Formation
Vascular Endothelial Growth Factor Binding
Retromer, Tubulation Complex
Protein Tyrosine Kinase Activity
Glomerular Capillary Formation
Lipid Binding
Regulation Of Macroautophagy
Platelet-derived Growth Factor Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet-derived Growth Factor Receptor Binding
Retina Vasculature Development In Camera-type Eye
Cardiac Myofibril Assembly
Regulation Of Glucose Metabolic Process
Cellular Response To Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Endosome Membrane
Membrane
Retromer Complex
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphorus Metabolic Process
Protein Autophosphorylation
Response To Growth Factor
Adrenal Gland Development
Kinase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Myofibril Assembly
Negative Regulation Of ERBB Signaling Pathway
Cellular Localization
Negative Regulation Of Catabolic Process
Phosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Cell Cycle Process
Endosome
Lipid Tube
Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Organelle Organization
Protein-containing Complex
Positive Regulation Of ERK1 And ERK2 Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Multivesicular Body, Internal Vesicle Lumen
Leptin Receptor Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Cell Migration Involved In Coronary Angiogenesis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
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