IRF8 and ZBTB17

Number of citations of the paper that reports this interaction (PMID 12904288)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		IRF8	ZBTB17
Gene Name		interferon regulatory factor 8	zinc finger and BTB domain containing 17
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Phagocytosis Immune Response Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide	Gastrulation With Mouth Forming Second Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Ectoderm Development Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 21131588 20062064) Diabetic retinopathy ( 21441570) Inflammatory bowel disease ( 23128233) Monocyte count ( 23314186) Multiple sclerosis ( 19525953 21833088) Rheumatoid arthritis ( 22446963) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23511034)	Dilated cardiomyopathy ( 21459883)
Protein-Protein Interactions		12 interactors: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	19 interactors: CDKN2B CREBBP DIS3 DNMT3A EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 IRF8 ITGB5 MAX MSX2 MYC PGR TMPRSS11A TOPBP1
Entrez ID		3394	7709
HPRD ID		03336	04968
Ensembl ID		ENSG00000140968	ENSG00000116809
Uniprot IDs		Q02556	Q13105
PDB IDs			2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2Q81 3M52
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Response To Cytokine Regulation Of Interleukin-12 Production Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Type I Interferon Production Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Membrane Protein Intracellular Domain Proteolysis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cytokine Biosynthetic Process RNA Biosynthetic Process Regulation Of Type I Interferon Production Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Interferon-gamma-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Membrane Protein Proteolysis Cellular Response To Interferon-gamma Immune Response Positive Regulation Of Interleukin-12 Production Regulation Of Metabolic Process NIK/NF-kappaB Signaling Defense Response Response To Interferon-gamma Immune System Process RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway	Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Gene Expression Gene Expression Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gland Development N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Chromatin Modification Multicellular Organismal Development Gland Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Mammary Gland Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Chromatin Organization Cellular Response To Lipid Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Duct Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mammary Gland Branching Involved In Pregnancy
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	10k 1p35 1p36 aboriginal affymetrix annotated arrangements cataract descent dysmorphism encompasses epha2 ephb2 erythematous harbour lod merlin monosomy overlaps pedigree penetrant positional rash rs1441834 rs966321 ruled segregating spans volkmann
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	10k 1p35 1p36 aboriginal affymetrix annotated arrangements cataract descent dysmorphism encompasses epha2 ephb2 erythematous harbour lod merlin monosomy overlaps pedigree penetrant positional rash rs1441834 rs966321 ruled segregating spans volkmann
Tagcloud (Intersection) ?