IRF8 and IRF6

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down, pull down)

		IRF8	IRF6
Description		interferon regulatory factor 8	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Keratinocyte Differentiation Skin Development Keratinocyte Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Stem Cell Proliferation Cranial Skeletal System Development Negative Regulation Of Stem Cell Proliferation
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 27863252 32888494 23314186 28193307 29403010) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 19525953 24076602 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe insulin-deficient type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)	Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	4 interacting genes: IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3394	3664
HPRD ID		03336	06227
Ensembl ID		ENSG00000140968	ENSG00000117595
Uniprot IDs		H3BRT4 Q02556	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Plasmacytoid Dendritic Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Development Type B Pancreatic Cell Maturation DNA Binding Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Ciliary Transition Fiber Pronucleus Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Morphogenesis Germinal Center B Cell Differentiation Kinetochore Assembly Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Negative Regulation Of RNA Metabolic Process Kinetochore Organization Regulation Of Metabolic Process Endocrine Pancreas Development
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