IRF8 and IRF6

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down, pull down)

		IRF8	IRF6
Gene Name		interferon regulatory factor 8	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Regulatory Region DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Phagocytosis Immune Response Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide	Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Cell Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 21131588 20062064) Diabetic retinopathy ( 21441570) Inflammatory bowel disease ( 23128233) Monocyte count ( 23314186) Multiple sclerosis ( 19525953 21833088) Rheumatoid arthritis ( 22446963) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23511034)	Cleft lip ( 20436469) Orofacial clefts ( 19270707 22863734)
Protein-Protein Interactions		12 interactors: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	5 interactors: IRF8 LBP RFX3 TLX2 ZBTB3
Entrez ID		3394	3664
HPRD ID		03336	06227
Ensembl ID		ENSG00000140968	ENSG00000117595
Uniprot IDs		Q02556	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Response To Cytokine Regulation Of Interleukin-12 Production Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Type I Interferon Production Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Membrane Protein Intracellular Domain Proteolysis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cytokine Biosynthetic Process RNA Biosynthetic Process Regulation Of Type I Interferon Production Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Interferon-gamma-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Membrane Protein Proteolysis Cellular Response To Interferon-gamma Immune Response Positive Regulation Of Interleukin-12 Production Regulation Of Metabolic Process NIK/NF-kappaB Signaling Defense Response Response To Interferon-gamma Immune System Process RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway	Negative Regulation Of Growth Of Symbiont In Host Cellular Response To Lipopolysaccharide Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Type B Pancreatic Cell Maturation Lipopolysaccharide Transport Transcription, DNA-templated Cellular Response To Molecule Of Bacterial Origin RNA Biosynthetic Process Defense Response To Bacterium Cilium-dependent Cell Motility Positive Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Growth Phagocytosis Glandular Epithelial Cell Maturation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway RNA Metabolic Process Positive Regulation Of Respiratory Burst Response To Lipopolysaccharide Negative Regulation Of Dendrite Morphogenesis Response To Molecule Of Bacterial Origin Gene Expression Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Positive Regulation Of Cytokine Production Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Opsonization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Positive Regulation Of Macrophage Activation Macromolecule Biosynthetic Process Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of DNA-templated Transcription, Initiation Enteric Nervous System Development Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Cellular Response To Lipid Regulation Of Metabolic Process Negative Regulation Of Dendrite Development Type B Pancreatic Cell Development Leukocyte Migration Involved In Inflammatory Response Regulation Of DNA-templated Transcription, Initiation Response To Bacterium Defense Response To Protozoan Regulation Of Tumor Necrosis Factor Biosynthetic Process
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Intersection) ?