HLA-DRB1 and ZDHHC17

Number of citations of the paper that reports this interaction (PMID 24705354)
0

Data Source:
BioGRID (two hybrid)

		HLA-DRB1	ZDHHC17
Gene Name		major histocompatibility complex, class II, DR beta 1	zinc finger, DHHC-type containing 17
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Integral Component Of Membrane Golgi-associated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Signal Transducer Activity Protein Binding Zinc Ion Binding Magnesium Ion Transmembrane Transporter Activity Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding
	Biological Process	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion	Signal Transduction Magnesium Ion Transport Protein Palmitoylation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 18576341) Cervical cancer ( 23482656) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lymphoma ( 23349640) Multiple sclerosis ( 22190364 19525953 19525955 18941528) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Response to ximelagatran treatment ( 17505501) Rheumatoid arthritis ( 21452313 17804836 18794853 17554300 20453841 20453842) Schizophrenia ( 23212062) Systemic lupus erythematosus ( 23273568 19838193) Systemic sclerosis ( 21779181) Type 1 diabetes ( 17632545) Ulcerative colitis ( 23128233 21297633 19122664 23511034)
Protein-Protein Interactions		9 interactors: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCH1 TRA TRB TRIM21 ZDHHC17	191 interactors: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCNE2 CDSN CENPBD1P1 CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM122C FAM135B FAM207A FAM9A FBXO18 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 HBG1 HECTD3 HIST1H2BH HIST1H3H HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT HYPM IFT20 IFT57 INPP5D JMJD7-PLA2G4B KIAA0141 KIAA0226L KIAA0408 KIAA0907 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LGALS9C LIN28A LMAN2L LOC401296 LOC554206 LRRC45 LY6G6C MANF MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF OBFC1 ODF2 OFCC1 OTUD7B OTX2 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SMARCB1 SNAP25 SOX14 SP2 SPRED2 SPRY4 SREBF2 SRSF4 STK25 SUMF2 SYT1 TAF8 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZCCHC6 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		3123	23390
HPRD ID		08349	09697
Ensembl ID		ENSG00000196126	ENSG00000186908
Uniprot IDs		D7RIH8 P01911 P01912 Q29974 Q5Y7D1	Q8IUH5
PDB IDs		1A6A 1BX2 1YMM 2WBJ	3EU9
Enriched GO Terms of Interacting Partners?		Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Interferon-gamma-mediated Signaling Pathway Immune System Process Cellular Response To Interferon-gamma Polysaccharide Assembly With MHC Class II Protein Complex Response To Interferon-gamma Protein Polyubiquitination Negative Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Activation Protein Complex Assembly Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Deubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Thymic T Cell Selection Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Viral Release From Host Cell Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Lipoprotein Transport Regulation Of Viral Entry Into Host Cell Magnesium Ion Transport Cellular Component Assembly Thymic T Cell Selection Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Cellular Protein Metabolic Process Response To Stimulus Protein Destabilization Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Palmitoylation Protein Modification By Small Protein Conjugation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response	Regulation Of Metabolic Process Transcription, DNA-templated RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Cellular Process Organelle Organization Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Neurotransmitter Uptake Developmental Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Golgi Organization Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Transcription, DNA-templated Chromatin Organization Cellular Component Assembly Regulation Of Gene Silencing Gene Silencing RNA 3'-end Processing Embryo Development Visual Learning Regulation Of Cell Projection Organization Visual Behavior RNA Processing
Tagcloud ?			1b atr atxn3 bcl11b cdkn1a cep290 cxcl5 dmxl1 ensured gfi gnal gnl3l gpr65 gtf2h3 il6st jem knocked lamp1 megakaryocytic mycbp pld1 rac3 rbbp6 reserve rigorous smc3 tmem30 tpr znf292
Tagcloud (Difference) ?			1b atr atxn3 bcl11b cdkn1a cep290 cxcl5 dmxl1 ensured gfi gnal gnl3l gpr65 gtf2h3 il6st jem knocked lamp1 megakaryocytic mycbp pld1 rac3 rbbp6 reserve rigorous smc3 tmem30 tpr znf292
Tagcloud (Intersection) ?