HLA-DRB1 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 18022694)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HLA-DRB1	TRIM21
Description		major histocompatibility complex, class II, DR beta 1	tripartite motif containing 21
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GO Annotations	Cellular Component	Golgi Membrane Immunological Synapse Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intermediate Filament Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Autolysosome Membrane	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding T Cell Receptor Binding CD4 Receptor Binding	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Inflammatory Response To Antigenic Stimulus Myeloid Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response Humoral Immune Response Cytoskeleton Organization Signal Transduction Epidermis Development Detection Of Bacterium Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macrophage Differentiation Regulation Of Interleukin-10 Production Regulation Of Interleukin-4 Production Negative Regulation Of Type II Interferon Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Kinase Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of T-helper Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein Tetramerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs		1D09C3 Glatiramer Glatiramer Glatiramer Coccidioides immitis spherule
Diseases		Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Asthma Dilated cardiomyopathy (DCM) Tuberculosis Type I diabetes mellitus
GWAS		A body shape index ( 34021172) Age-related hearing impairment ( 34108613) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-Merkel cell polyomavirus IgG seropositivity ( 33204752) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Arterial stiffness index ( 31235810) Arthritis (juvenile idiopathic) ( 18576341) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Aspartate aminotransferase levels ( 33339817 33547301) Asthma ( 29273806 30929738 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 28928442) Childhood onset ulcerative colitis ( 29562276) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Chronic lymphocytic leukemia ( 26956414) Cold sores ( 28928442) Creatinine levels ( 29403010) Crohn's disease ( 23266558 23850713 26891255) Drug-induced liver injury (flucloxacillin) ( 30661239) Enteric fever ( 25383971) Eosinophil count ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate ( 30604766) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Family history of Alzheimer's disease ( 30617256) Giant cell arteritis ( 25817017 28041642) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 33736632) Hepatitis B vaccine response ( 24282030) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929 25305756 26028593) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 31596875) Lapatinib-induced hepatotoxicity ( 25987243) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Lumiracoxib-related liver injury ( 20639878) Lung adenocarcinoma ( 28604730) Lymphocyte count ( 29403010) Lymphoma ( 23349640) Medication use (immunosuppressants) ( 31015401) Metabolic syndrome ( 31589552) Mixed cellularity Hodgkin lymphoma ( 29196614) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis ( 18941528 19525953 19525955 22190364 27386562) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neurofibrillary tangles ( 25188341) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417 29196614) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 32201043) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Pemphigus vulgaris ( 29857070) Persistent hepatitis B virus infection ( 33736632) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 28062665) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Response to interferon beta therapy ( 21502966) Reticulocyte count ( 27863252) Rheumatoid arthritis ( 17554300 17804836 18794853 20453841 21452313 24390342 25014791 28118524 30423114 32723749 33514426) Rheumatoid arthritis (ACPA-negative) ( 24532677 33514426) Rheumatoid arthritis (ACPA-positive) ( 33514426) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Scarlet fever ( 28928442) Schizophrenia ( 23212062) Serum alkaline phosphatase levels ( 33547301) Serum IgE levels ( 25488688) Shingles ( 28928442) Sjögren's syndrome ( 24097066 28076899) Skin and soft tissue Staphylococcus aureus infection ( 26450422) Small cell lung carcinoma ( 28604730) Staphylococcus aureus infection ( 26450422) Strep throat ( 28928442) Systemic lupus erythematosus ( 19838193 19838195 23273568 24871463 26606652 32771030) Systemic sclerosis ( 21779181 30247649) Takayasu arteritis ( 23830517 25604533 33308445) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 28928442 29036319) Type 1 diabetes ( 17632545) Ulcerative colitis ( 19122664 21297633 23128233 23511034 28067908) Ulcerative colitis or Crohn's disease ( 21699788) Vitiligo ( 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Yeast infection ( 28928442)	Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		11 interacting genes: CTAG1B HLA-DMA HLA-DRA MAGEA3 MAILR MARCHF1 RUNX1 TRA TRB TRIM21 ZDHHC17	86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		3123	6737
HPRD ID		08349	00170
Ensembl ID		ENSG00000196126	ENSG00000132109
Uniprot IDs		A0A224MM52 A2BFX2 D7RIG5 D7RIH8 P01911 Q5Y7D1 X5DNQ0	P19474
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 7N19 7NZE 7Z0Q 8PJG 8TBP 8TRL 8TRQ 8TRR 8VRW	2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Antigen Processing And Presentation Of Peptide Antigen Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell Adaptive Immune Response Antigen Processing And Presentation Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex T Cell Mediated Cytotoxicity T Cell Receptor Complex Late Endosome Membrane MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Biotic Stimulus Peptide Antigen Binding T Cell Mediated Immunity Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Immune System Process Positive Regulation Of T Cell Activation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Maturation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Activation Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of CD4-positive, Alpha-beta T Cell Activation Lysosomal Membrane Cytoplasmic Vesicle Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Core-binding Factor Complex Myeloid Dendritic Cell Antigen Processing And Presentation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Trans-Golgi Network Membrane Cardiac Muscle Tissue Regeneration Negative Regulation Of Protein Deubiquitination Lymphocyte Mediated Immunity	Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy
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