HLA-DRB1 and RUNX1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HLA-DRB1	RUNX1
Description		major histocompatibility complex, class II, DR beta 1	RUNX family transcription factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Immunological Synapse Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intermediate Filament Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Autolysosome Membrane	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding T Cell Receptor Binding CD4 Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Inflammatory Response To Antigenic Stimulus Myeloid Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response Humoral Immune Response Cytoskeleton Organization Signal Transduction Epidermis Development Detection Of Bacterium Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macrophage Differentiation Regulation Of Interleukin-10 Production Regulation Of Interleukin-4 Production Negative Regulation Of Type II Interferon Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Kinase Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of T-helper Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein Tetramerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Plasminogen Activation Hemopoiesis Myeloid Cell Differentiation Neuron Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement Regulation Of Multicellular Organismal Development
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Pre-NOTCH Transcription and Translation SLC-mediated transport of organic cations RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis SARS-CoV-1 activates/modulates innate immune responses Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs		1D09C3 Glatiramer Glatiramer Glatiramer Coccidioides immitis spherule
Diseases		Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Asthma Dilated cardiomyopathy (DCM) Tuberculosis Type I diabetes mellitus	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Acute myeloid leukemia (AML) Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		A body shape index ( 34021172) Age-related hearing impairment ( 34108613) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-Merkel cell polyomavirus IgG seropositivity ( 33204752) Antisaccade task score ( 31596458) Appendicular lean mass ( 33097823) Arterial stiffness index ( 31235810) Arthritis (juvenile idiopathic) ( 18576341) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Aspartate aminotransferase levels ( 33339817 33547301) Asthma ( 29273806 30929738 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 28928442) Childhood onset ulcerative colitis ( 29562276) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Chronic lymphocytic leukemia ( 26956414) Cold sores ( 28928442) Creatinine levels ( 29403010) Crohn's disease ( 23266558 23850713 26891255) Drug-induced liver injury (flucloxacillin) ( 30661239) Enteric fever ( 25383971) Eosinophil count ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate ( 30604766) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Family history of Alzheimer's disease ( 30617256) Giant cell arteritis ( 25817017 28041642) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 33736632) Hepatitis B vaccine response ( 24282030) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929 25305756 26028593) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 31596875) Lapatinib-induced hepatotoxicity ( 25987243) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Lumiracoxib-related liver injury ( 20639878) Lung adenocarcinoma ( 28604730) Lymphocyte count ( 29403010) Lymphoma ( 23349640) Medication use (immunosuppressants) ( 31015401) Metabolic syndrome ( 31589552) Mixed cellularity Hodgkin lymphoma ( 29196614) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis ( 18941528 19525953 19525955 22190364 27386562) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neurofibrillary tangles ( 25188341) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417 29196614) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 32201043) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Pemphigus vulgaris ( 29857070) Persistent hepatitis B virus infection ( 33736632) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 28062665) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Response to interferon beta therapy ( 21502966) Reticulocyte count ( 27863252) Rheumatoid arthritis ( 17554300 17804836 18794853 20453841 21452313 24390342 25014791 28118524 30423114 32723749 33514426) Rheumatoid arthritis (ACPA-negative) ( 24532677 33514426) Rheumatoid arthritis (ACPA-positive) ( 33514426) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Scarlet fever ( 28928442) Schizophrenia ( 23212062) Serum alkaline phosphatase levels ( 33547301) Serum IgE levels ( 25488688) Shingles ( 28928442) Sjögren's syndrome ( 24097066 28076899) Skin and soft tissue Staphylococcus aureus infection ( 26450422) Small cell lung carcinoma ( 28604730) Staphylococcus aureus infection ( 26450422) Strep throat ( 28928442) Systemic lupus erythematosus ( 19838193 19838195 23273568 24871463 26606652 32771030) Systemic sclerosis ( 21779181 30247649) Takayasu arteritis ( 23830517 25604533 33308445) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 28928442 29036319) Type 1 diabetes ( 17632545) Ulcerative colitis ( 19122664 21297633 23128233 23511034 28067908) Ulcerative colitis or Crohn's disease ( 21699788) Vitiligo ( 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Yeast infection ( 28928442)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Brain-derived neurotrophic factor levels ( 33345186) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota alpha diversity (Chao1 index) ( 33208821) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 28196072 29146897 27182965) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Stroke ( 32693751) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: CTAG1B HLA-DMA HLA-DRA MAGEA3 MAILR MARCHF1 RUNX1 TRA TRB TRIM21 ZDHHC17	119 interacting genes: ABCA2 ABHD14A AGTPBP1 ALKBH6 APEH AR ARGLU1 ARID5B ATP13A1 B4GAT1 BAG3 BAG4 BTBD2 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK2 CDK6 CEBPA CEBPB CERCAM CLIP4 CNOT3 CNRIP1 COPA COPRS DAZAP2 DNMT1 DTX2 DZIP3 EEF2 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 FOXRED1 GCC1 GDI1 GSK3A GTPBP6 HGS HIPK1 HIPK2 HLA-DRB1 IDS IKZF1 IKZF3 JUN KAT6A KAT6B MAGI3 MAPK1 ME3 METTL26 MPPED2 MSTO1 MYOD1 NCOR1 NCOR2 NDST1 NFKBID OLFM1 OLIG3 PAX5 PICK1 PKD1 PLEKHB1 PLEKHB2 PPP3CB PRDM4 PRMT1 PRRC2A PSMB4 RBFOX3 RBM14 RNF38 RNF44 SEC31B SNRNP70 SNRPC SPEN SPI1 STUB1 SULT4A1 SUV39H1 TAFAZZIN TCERG1 TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TMEM222 TOLLIP TRIM5 TUBA1B UBE2L6 UHRF2 UROD USP10 UXT VDR VPS37C VPS39 WBP2 WWP1 WWTR1 YAP1 ZMYM4
Entrez ID		3123	861
HPRD ID		08349	01043
Ensembl ID		ENSG00000196126	ENSG00000159216
Uniprot IDs		A0A224MM52 A2BFX2 D7RIG5 D7RIH8 P01911 Q5Y7D1 X5DNQ0	Q01196
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 7N19 7NZE 7Z0Q 8PJG 8TBP 8TRL 8TRQ 8TRR 8VRW	1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Antigen Processing And Presentation Of Peptide Antigen Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell Adaptive Immune Response Antigen Processing And Presentation Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex T Cell Mediated Cytotoxicity T Cell Receptor Complex Late Endosome Membrane MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Biotic Stimulus Peptide Antigen Binding T Cell Mediated Immunity Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Immune System Process Positive Regulation Of T Cell Activation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Maturation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Activation Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of CD4-positive, Alpha-beta T Cell Activation Lysosomal Membrane Cytoplasmic Vesicle Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Core-binding Factor Complex Myeloid Dendritic Cell Antigen Processing And Presentation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Trans-Golgi Network Membrane Cardiac Muscle Tissue Regeneration Negative Regulation Of Protein Deubiquitination Lymphocyte Mediated Immunity	Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Coactivator Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cellular Developmental Process Regulation Of Cell Differentiation Chromatin Binding Developmental Process Leukocyte Differentiation Mononuclear Cell Differentiation Chromatin Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Chromatin Remodeling Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription By RNA Polymerase II
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?