SRI and RYR2

Number of citations of the paper that reports this interaction (PMID 7592856)
15

Data Source:
HPRD (in vivo)

		SRI	RYR2
Gene Name		sorcin	ryanodine receptor 2 (cardiac)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI
Entrez ID		6717	6262
HPRD ID		01680	01619
Ensembl ID		ENSG00000075142	ENSG00000198626
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	Q92736
PDB IDs		1JUO 2JC2
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly
Tagcloud (Intersection) ?