SRI and SHBG

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SRI	SHBG
Gene Name		sorcin	sex hormone-binding globulin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Androgen Binding
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Primary Spermatocyte Growth
Pathways		Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		6717	6462
HPRD ID		01680	01646
Ensembl ID		ENSG00000075142	ENSG00000129214
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278
PDB IDs		1JUO 2JC2	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Intersection) ?