SRI and PDE4C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SRI	PDE4C
Description		sorcin	phosphodiesterase 4C
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Z Disc T-tubule Vesicle Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Extracellular Exosome	Extracellular Space Cytosol Cilium Cell Projection
	Molecular Function	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Calcium Ion Transport Signal Transduction Negative Regulation Of Heart Rate Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction	CAMP Catabolic Process Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	DARPP-32 events G alpha (s) signalling events
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS			A body shape index ( 34021172) Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		25 interacting genes: ALG2 ANXA11 ANXA7 ATP2A2 CACNA1C CACNA1S CALCOCO2 GCA GRIK1 MORC3 MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 RYR3 SHBG SIGMAR1 SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1	9 interacting genes: DDIT4L GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A
Entrez ID		6717	5143
HPRD ID		01680	02529
Ensembl ID		ENSG00000075142	ENSG00000105650
Uniprot IDs		B4DHQ6 P30626	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs		1JUO 2JC2 4U8D 4UPG 4USL 5MRA	2QYM
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Caffeine Response To Caffeine Intracellular Signaling Cassette Sarcoplasmic Reticulum Monoatomic Ion Channel Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Response To Alkaloid Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Binding Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Sarcoplasmic Reticulum Membrane Calcium Ion Transport Muscle System Process Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Calcium Ion Transmembrane Transport Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Action Potential Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion L-type Voltage-gated Calcium Channel Complex Response To Metal Ion Regulation Of Muscle Contraction Intracellular Signal Transduction Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Epinephrine Stimulus Calcium Ion Transport Into Cytosol High Voltage-gated Calcium Channel Activity Calmodulin Binding S100 Protein Binding Muscle Contraction Regulation Of Cardiac Muscle Contraction Response To Epinephrine Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Contraction Regulation Of Hydrogen Peroxide Metabolic Process Response To Magnesium Ion	Somite Specification Segment Specification HMG Box Domain Binding Somite Development Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Embryonic Pattern Specification Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Response To Metformin Negative Regulation Of Leukocyte Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Natural Killer Cell Chemotaxis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Sclerotome Development Regulation Of Cell Migration Habenula Development Pallium Development Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Motility Chromatin Regulation Of Locomotion Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification
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