SRI and CACNA1S

Number of citations: 0 (PubMedID 9668070)
Data Source: HPRD (in vitro)

		SRI	CACNA1S
Name		sorcin	calcium voltage-gated channel subunit alpha1 S
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Z Disc T-tubule Vesicle Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Sarcoplasmic Reticulum T-tubule I Band Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Small Molecule Binding Metal Ion Binding Molecular Function Activator Activity
	Biological Process	Calcium Ion Transport Signal Transduction Negative Regulation Of Heart Rate Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Skeletal System Development Extraocular Skeletal Muscle Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Skeletal Muscle Tissue Development Myoblast Fusion Neuromuscular Junction Development Monoatomic Ion Transmembrane Transport Skeletal Muscle Adaptation Positive Regulation Of Muscle Contraction Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Muscle Cell Development Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Calcium Ion Import Across Plasma Membrane
Pathways		Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	NCAM1 interactions
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases		None	Hypokalemic periodic paralysis (HypoPP)
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac Troponin-T levels ( 31014085 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Permanent tooth development ( 21931568 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Tooth agenesis ( 29364747 ) Ulcerative colitis ( 28067908 20228799 ) Urinary albumin-to-creatinine ratio ( 31511532 )
Novel Interactors		None recorded	2 novel interactors: KDR SLC25A17
Interacting Genes		25 interacting genes: ALG2 ANXA11 ANXA7 ATP2A2 CACNA1C CACNA1S CALCOCO2 GCA GRIK1 MORC3 MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 RYR3 SHBG SIGMAR1 SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1	9 interacting genes: CCDC106 CYSRT1 MEOX2 NHERF4 REL RIMS2 RYR1 SRI TNKS
Entrez ID		6717	779
HPRD ID		01680	00248
Ensembl ID		ENSG00000075142	ENSG00000081248
Uniprot IDs		B4DHQ6 P30626	B1ALM3 Q13698
PDB IDs		1JUO 2JC2 4U8D 4UPG 4USL 5MRA	2VAY 6B27
GO Terms Enriched among Interactors		Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Caffeine Response To Caffeine Intracellular Signaling Cassette Sarcoplasmic Reticulum Monoatomic Ion Channel Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Response To Alkaloid Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Binding Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Sarcoplasmic Reticulum Membrane Calcium Ion Transport Muscle System Process Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Calcium Ion Transmembrane Transport Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Action Potential Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion L-type Voltage-gated Calcium Channel Complex Response To Metal Ion Regulation Of Muscle Contraction Intracellular Signal Transduction Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Epinephrine Stimulus Calcium Ion Transport Into Cytosol High Voltage-gated Calcium Channel Activity Calmodulin Binding S100 Protein Binding Muscle Contraction Regulation Of Cardiac Muscle Contraction Response To Epinephrine Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Contraction Regulation Of Hydrogen Peroxide Metabolic Process Response To Magnesium Ion	Regulation Of CGMP-mediated Signaling Epithelium Development Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Sarcoplasmic Reticulum Membrane FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Guanylate Cyclase Inhibitor Activity