SRI and CACNA1S

Number of citations of the paper that reports this interaction (PMID 9668070)
16

Data Source:
HPRD (in vitro)

		SRI	CACNA1S
Gene Name		sorcin	calcium channel, voltage-dependent, L type, alpha 1S subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Sarcoplasmic Reticulum T-tubule I Band
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Skeletal System Development Extraocular Skeletal Muscle Development Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Axon Guidance Myoblast Fusion Neuromuscular Junction Development Regulation Of Ion Transmembrane Transport Skeletal Muscle Adaptation Skeletal Muscle Fiber Development Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Ion channel transport Stimuli-sensing channels	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Permanent tooth development ( 21931568)
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	4 interactors: PDZD3 RIMS2 RYR1 SRI
Entrez ID		6717	779
HPRD ID		01680	00248
Ensembl ID		ENSG00000075142	ENSG00000081248
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	B1ALM3 Q13698
PDB IDs		1JUO 2JC2	2VAY
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Cyclic-nucleotide-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Intracellular Sequestering Of Iron Ion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Membrane Potential Muscle Organ Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transport Regulation Of High Voltage-gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Relaxation Of Muscle Ion Transport Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Cellular Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Regulation Of Ion Transmembrane Transport Transport Cellular Cation Homeostasis Regulation Of Cell Communication By Electrical Coupling Cellular Ion Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Metal Ion Homeostasis Negative Regulation Of Transcription Regulatory Region DNA Binding Muscle Structure Development Heart Development Ossification Involved In Bone Maturation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Chemical Homeostasis Bone Maturation Ion Homeostasis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Regulation Of CGMP Biosynthetic Process CAMP-mediated Signaling Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Negative Regulation Of Lyase Activity Cellular Localization Regulation Of Ion Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Intersection) ?