SRI and CACNA1C

Number of citations of the paper that reports this interaction (PMID 9668070)
16

Data Source:
HPRD (in vitro)

		SRI	CACNA1C
Gene Name		sorcin	calcium channel, voltage-dependent, L type, alpha 1C subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Caveolar Macromolecular Signaling Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Neuronal Cell Body Dendritic Shaft
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Enzyme Binding Metal Ion Binding Alpha-actinin Binding
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Axon Guidance Adult Walking Behavior Regulation Of Blood Pressure Visual Learning Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Ion-dependent Exocytosis Regulation Of Vasoconstriction Insulin Secretion Growth Hormone Secretion Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Glucose Homeostasis Small Molecule Metabolic Process Regulation Of Organ Growth Regulation Of Insulin Secretion Smooth Muscle Contraction Involved In Micturition Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Ion channel transport Stimuli-sensing channels	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion
Drugs			Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Red blood cell traits ( 23222517) Schizophrenia ( 21926974 22688191) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	11 interactors: CABP1 CACNB3 COPS5 GNB1 HDAC4 PCBD1 PPM1A PRKACA RIMS1 RYR2 SRI
Entrez ID		6717	775
HPRD ID		01680	00246
Ensembl ID		ENSG00000075142
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	Q13936
PDB IDs		1JUO 2JC2	1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Catecholamine Stimulus Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Import Into Nucleus Regulation Of Binding Regulation Of Intracellular Protein Transport Regulation Of Ion Transport Regulation Of Heart Rate Regulation Of Membrane Potential Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Protein Transport Calcium-mediated Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Negative Regulation Of Intracellular Transport Negative Regulation Of Transport Cellular Metal Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell-cell Signaling Response To Epinephrine Second-messenger-mediated Signaling Cellular Cation Homeostasis Regulation Of Protein Binding Negative Regulation Of Cation Channel Activity Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Response To Organonitrogen Compound Regulation Of Ion Homeostasis
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Intersection) ?