SRI and GCA

Number of citations of the paper that reports this interaction (PMID 12804766)
1

Data Source:
HPRD (in vitro, in vivo)

		SRI	GCA
Gene Name		sorcin	grancalcin, EF-hand calcium binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Proteolysis Membrane Fusion
Pathways		Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	5 interactors: ATXN1 LCP1 MAGEA8 RBFOX1 SRI
Entrez ID		6717	25801
HPRD ID		01680	06122
Ensembl ID		ENSG00000075142
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	P28676
PDB IDs		1JUO 2JC2	1F4O 1F4Q 1K94 1K95
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Intracellular Sequestering Of Iron Ion Protein Kinase A Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Protein Transport Regulation Of Membrane Potential Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Cell Communication By Electrical Coupling
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	acanthamoeba acquisition agc ancestral arrays cag clustering coevolution coincided duplications enlargement evolutionary falciparum incorporate insects lineages metazoans motifs nematodes opa overrepresented propensity ribosomal rnas slippage tbp underrepresentation vertebrates wheat
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	acanthamoeba acquisition agc ancestral arrays cag clustering coevolution coincided duplications enlargement evolutionary falciparum incorporate insects lineages metazoans motifs nematodes opa overrepresented propensity ribosomal rnas slippage tbp underrepresentation vertebrates wheat
Tagcloud (Intersection) ?