SRI and RYR3

Number of citations of the paper that reports this interaction (PubMedID 33060591)
64

Data Source:
BioGRID (pull down)

		SRI	RYR3
Description		sorcin	ryanodine receptor 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Z Disc T-tubule Vesicle Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Extracellular Exosome	Smooth Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma
	Molecular Function	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Calcium Ion Transport Signal Transduction Negative Regulation Of Heart Rate Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP
Pathways		Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	Stimuli-sensing channels Ion homeostasis
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid atherosclerosis in HIV infection ( 20009918) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hepcidin/ferritin ratio ( 27846281) Hippocampal volume ( 31530798) Malaria ( 31844061) Parkinson's disease progression (cognitive) ( 33958783) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Urinary albumin excretion ( 32277301)
Interacting Genes		25 interacting genes: ALG2 ANXA11 ANXA7 ATP2A2 CACNA1C CACNA1S CALCOCO2 GCA GRIK1 MORC3 MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 RYR3 SHBG SIGMAR1 SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1	7 interacting genes: BCL2L1 FKBP1A FKBP1B HNF1A RYR2 SRI TIAM1
Entrez ID		6717	6263
HPRD ID		01680	01620
Ensembl ID		ENSG00000075142	ENSG00000198838
Uniprot IDs		B4DHQ6 P30626	A0A0U1RRH1 Q15413
PDB IDs		1JUO 2JC2 4U8D 4UPG 4USL 5MRA	4ERV 6UHA 6UHB 6UHE 6UHH
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Caffeine Response To Caffeine Intracellular Signaling Cassette Sarcoplasmic Reticulum Monoatomic Ion Channel Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Response To Alkaloid Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Binding Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Sarcoplasmic Reticulum Membrane Calcium Ion Transport Muscle System Process Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Calcium Ion Transmembrane Transport Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Action Potential Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion L-type Voltage-gated Calcium Channel Complex Response To Metal Ion Regulation Of Muscle Contraction Intracellular Signal Transduction Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Epinephrine Stimulus Calcium Ion Transport Into Cytosol High Voltage-gated Calcium Channel Activity Calmodulin Binding S100 Protein Binding Muscle Contraction Regulation Of Cardiac Muscle Contraction Response To Epinephrine Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Contraction Regulation Of Hydrogen Peroxide Metabolic Process Response To Magnesium Ion	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Z Disc Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Muscle Contraction Regulation Of Heart Contraction Calcium Channel Regulator Activity Regulation Of Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Metal Ion Transport FK506 Binding 'de Novo' Protein Folding Regulation Of Heart Rate Negative Regulation Of Heart Rate Regulation Of Monoatomic Ion Transport Response To Redox State Negative Regulation Of Heart Contraction Calcium-mediated Signaling Regulation Of System Process Negative Regulation Of Blood Circulation Calcium Channel Complex Protein Refolding Regulation Of Cardiac Muscle Cell Contraction Peptidyl-prolyl Cis-trans Isomerase Activity Cellular Response To Alkaloid Calcium Ion Transport Regulation Of Transport Ventricular Cardiac Muscle Tissue Morphogenesis Epithelial Cell Apoptotic Process Insulin Secretion Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Protein Localization Cardiac Muscle Tissue Morphogenesis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Peptide Hormone Secretion
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