SRD5A1 and CD44

Data Source: HiPPIP (Novel)

		SRD5A1	CD44
Name		steroid 5 alpha-reductase 1	CD44 molecule (IN blood group)
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Cell Body Fiber	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Amide Binding 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity NADPH Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding
	Biological Process	Urogenital System Development Liver Development Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Androgen Catabolic Process Sex Determination Sex Differentiation Steroid Metabolic Process Androgen Metabolic Process Male Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Muscle Activity Diterpenoid Metabolic Process Spinal Cord Development Hippocampus Development Thalamus Development Hypothalamus Development Pituitary Gland Development Cerebral Cortex Development Cell Differentiation Male Genitalia Development Female Genitalia Development Response To Follicle-stimulating Hormone Response To Estradiol Cellular Response To Insulin Stimulus Response To Testosterone Serotonin Metabolic Process Progesterone Metabolic Process Response To Estrogen Bone Development Response To Growth Hormone Response To Fungicide Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Testosterone Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Epinephrine Stimulus Cellular Response To Serotonin	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis
Pathways		Androgen biosynthesis	Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		Levonorgestrel Spironolactone Dutasteride Finasteride Norgestrel	Bivatuzumab Hyaluronic acid
Diseases		None	Gastric cancer
GWAS		Response to amphetamines ( 22952603 ) Visceral fat ( 22589738 )	Bone mineral density (hip) ( 30172743 ) Glycemic traits (pleiotropy) ( 31021400 ) Intake of sweets ( 31005972 ) Response to Vitamin E supplementation ( 22437554 ) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Uterine fibroids ( 31649266 ) Vitiligo ( 22561518 27723757 )
Novel Interactors		1 novel interactors: CD44	9 novel interactors: BDNF CAT CSTF3 DPT LMO2 MAP3K13 NONO RIMS2 SRD5A1
Interacting Genes		None recorded	61 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		6715	960
HPRD ID		01699	00115
Ensembl ID		ENSG00000145545	ENSG00000026508
Uniprot IDs		B7Z4D8 P18405	P16070
PDB IDs		Not available	1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
GO Terms Enriched among Interactors		Positive Regulation Of Monocyte Aggregation Macrophage Migration Inhibitory Factor Receptor Complex Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronic Acid Binding Positive Regulation Of Heterotypic Cell-cell Adhesion Lamellipodium Membrane Leukocyte Aggregation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Glycosaminoglycan Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Hyaluronan Catabolic Process Hyaluronan Metabolic Process Wound Healing, Spreading Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction By P53 Class Mediator Glycosaminoglycan Metabolic Process Cytokine Receptor Activity Regulation Of Lamellipodium Organization Leukocyte Cell-cell Adhesion Collagen Binding Microvillus Secretory Granule Membrane Cartilage Development Cell-matrix Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Cell-substrate Adhesion Carbohydrate Derivative Catabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Transmembrane Signaling Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Morphogenesis Basolateral Plasma Membrane Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Response To Growth Factor	Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death