SRD5A1

Name	steroid 5 alpha-reductase 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: CD44
Interactors	None recorded
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Cell Body Fiber
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Amide Binding 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity NADPH Binding
	Biological Process	Urogenital System Development Liver Development Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Androgen Catabolic Process Sex Determination Sex Differentiation Steroid Metabolic Process Androgen Metabolic Process Male Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Muscle Activity Diterpenoid Metabolic Process Spinal Cord Development Hippocampus Development Thalamus Development Hypothalamus Development Pituitary Gland Development Cerebral Cortex Development Cell Differentiation Male Genitalia Development Female Genitalia Development Response To Follicle-stimulating Hormone Response To Estradiol Cellular Response To Insulin Stimulus Response To Testosterone Serotonin Metabolic Process Progesterone Metabolic Process Response To Estrogen Bone Development Response To Growth Hormone Response To Fungicide Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Testosterone Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Epinephrine Stimulus Cellular Response To Serotonin
Pathways	Androgen biosynthesis
Drugs	Levonorgestrel Spironolactone Dutasteride Finasteride Norgestrel
GWAS	Response to amphetamines ( 22952603 ) Visceral fat ( 22589738 )
Entrez ID	6715
HPRD ID	01699
Ensembl ID	ENSG00000145545
Uniprot IDs	B7Z4D8 P18405
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Positive Regulation Of Monocyte Aggregation Macrophage Migration Inhibitory Factor Receptor Complex Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronic Acid Binding Positive Regulation Of Heterotypic Cell-cell Adhesion Lamellipodium Membrane Leukocyte Aggregation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Glycosaminoglycan Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Hyaluronan Catabolic Process Hyaluronan Metabolic Process Wound Healing, Spreading Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction By P53 Class Mediator Glycosaminoglycan Metabolic Process Cytokine Receptor Activity Regulation Of Lamellipodium Organization Leukocyte Cell-cell Adhesion Collagen Binding Microvillus Secretory Granule Membrane Cartilage Development Cell-matrix Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Cell-substrate Adhesion Carbohydrate Derivative Catabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intrinsic Apoptotic Signaling Pathway Transmembrane Signaling Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Morphogenesis Basolateral Plasma Membrane Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Response To Growth Factor