SP2 and FHL2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SP2	FHL2
Gene Name		Sp2 transcription factor	four and a half LIM domains 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Histone Deacetylase Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Immune Response Multicellular Organism Growth Fibroblast Proliferation Embryonic Organ Development Cardiovascular System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP BANP E2F1 FHL2 MCM7 NKX3-1 ZDHHC17	92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		6668	2274
HPRD ID		03481	04026
Ensembl ID		ENSG00000167182	ENSG00000115641
Uniprot IDs		Q02086	J3KNW4 Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Response To Oxygen Levels Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway RNA Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Atrial Cardiac Muscle Cell Development Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Estrogen Receptor Binding Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Lens Fiber Cell Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Apoptotic Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Axon Choice Point Recognition Anoikis Regulation Of Cell Cycle Phase Transition Apoptotic Process Negative Regulation Of Receptor Binding Programmed Cell Death Regulation Of Binding Transcription, DNA-templated	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis
Tagcloud ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?