SP2 and NKX3-1

Number of citations of the paper that reports this interaction (PMID 16201967)
10

Data Source:
BioGRID (two hybrid)

		SP2	NKX3-1
Gene Name		Sp2 transcription factor	NK3 homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Intracellular Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Histone Deacetylase Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Androgen Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Protein Kinase Activator Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding
	Biological Process	In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Immune Response Multicellular Organism Growth Fibroblast Proliferation Embryonic Organ Development Cardiovascular System Development	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP BANP E2F1 FHL2 MCM7 NKX3-1 ZDHHC17	32 interactors: AEN CCT7 CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 STRA13 TEX264 TOPORS TPT1 WDR77
Entrez ID		6668	4824
HPRD ID		03481	03620
Ensembl ID		ENSG00000167182	ENSG00000167034
Uniprot IDs		Q02086	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Response To Oxygen Levels Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway RNA Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Atrial Cardiac Muscle Cell Development Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Estrogen Receptor Binding Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Lens Fiber Cell Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Apoptotic Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Axon Choice Point Recognition Anoikis Regulation Of Cell Cycle Phase Transition Apoptotic Process Negative Regulation Of Receptor Binding Programmed Cell Death Regulation Of Binding Transcription, DNA-templated	Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Embryonic Eye Morphogenesis Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Embryonic Camera-type Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Eye Morphogenesis Biosynthetic Process Megakaryocyte Differentiation Trophectodermal Cell Differentiation Camera-type Eye Development Eye Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Erythrocyte Differentiation Erythrocyte Homeostasis Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Camera-type Eye Morphogenesis Organ Morphogenesis Myeloid Cell Homeostasis Organ Development Embryonic Organ Development Glandular Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Embryonic Process Involved In Female Pregnancy Sensory Organ Development Prostate Gland Development Regulation Of RNA Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Tissue Development System Development Homeostasis Of Number Of Cells
Tagcloud ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural
Tagcloud (Difference) ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural
Tagcloud (Intersection) ?