SP2 and E2F1

Number of citations of the paper that reports this interaction (PMID 10547281)
20

Data Source:
HPRD (in vivo, in vitro)

		SP2	E2F1
Gene Name		Sp2 transcription factor	E2F transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Histone Deacetylase Binding Metal Ion Binding	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Immune Response Multicellular Organism Growth Fibroblast Proliferation Embryonic Organ Development Cardiovascular System Development	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP BANP E2F1 FHL2 MCM7 NKX3-1 ZDHHC17	70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ
Entrez ID		6668	1869
HPRD ID		03481	01806
Ensembl ID		ENSG00000167182	ENSG00000101412
Uniprot IDs		Q02086	Q01094 Q9BSD8
PDB IDs			1H24 1O9K 2AZE
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Response To Oxygen Levels Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway RNA Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Atrial Cardiac Muscle Cell Development Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Estrogen Receptor Binding Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Lens Fiber Cell Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Apoptotic Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Axon Choice Point Recognition Anoikis Regulation Of Cell Cycle Phase Transition Apoptotic Process Negative Regulation Of Receptor Binding Programmed Cell Death Regulation Of Binding Transcription, DNA-templated	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Difference) ?		am276 amb amb357 amb374 baculovirus capsid conferred dimension drastic enveloped filamentous gag helical heptadecapeptide hkarvlaeamsqvtnsa junctions ma mhr nucleocapsid p6gag packing polyprotein separating sp1 spacer spherical sphericity symmetry ultrastructural	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Intersection) ?