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SP1 and NCOR1
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical)
HPRD
(in vitro, in vivo)
SP1
NCOR1
Description
Sp1 transcription factor
nuclear receptor corepressor 1
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Protein-DNA Complex
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Metal Ion Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Receptor Binding
Histone Deacetylase Binding
Nuclear Thyroid Hormone Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Cellular Response To Insulin Stimulus
Response To Hydroperoxide
Cellular Response To Zinc Ion Starvation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Host-mediated Activation Of Viral Transcription
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Cellular Response To Estrogen Stimulus
Positive Regulation Of Amyloid-beta Formation
Cellular Response To Wortmannin
Positive Regulation Of Hydrogen Sulfide Biosynthetic Process
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Ketone Metabolic Process
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Rhythmic Process
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of MiRNA Transcription
Pathways
PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Regulation of CDH11 gene transcription
Regulation of CDH11 gene transcription
Positive Regulation of CDH1 Gene Transcription
NFE2L2 regulating tumorigenic genes
TGFBR3 expression
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Cytoprotection by HMOX1
Heme signaling
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Hypospadias (moderate to severe) (
31856834
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil percentage of white cells (
27863252
)
Parkinsonism in frontotemporal lobe dementia (
29724592
)
Percentage gas trapping (
26030696
)
Progressive supranuclear palsy (
30089514
)
Red blood cell count (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte count (
32888494
)
Interacting Genes
149 interacting genes:
AATF
AHR
AKT1
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
CTCFL
CTNNB1
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KAT2B
KIF1A
KLF10
KLF4
KLF6
LDB1
LINC00955
LMO2
MAP1LC3A
MAPK1
MAPK3
MAPK8
MBD1
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MTREX
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NPM1
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RMP64
RNF4
RORA
RXRA
SENP6
SF3A1
SHC1
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO2
TAF4
TAL1
TBP
TLX3
TP53
TP73
TPI1
VEGFA
VHL
YY1
ZBTB16
ZBTB2
ZBTB5
ZBTB7A
98 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GABARAP
GABARAPL1
GABARAPL2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MAP1LC3A
MAP1LC3B
MAP1LC3C
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
OVOL2
PDCD2
PHB1
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
PTOV1
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB5
ZBTB7A
ZMYND11
Entrez ID
6667
9611
HPRD ID
01796
02911
Ensembl ID
ENSG00000185591
ENSG00000141027
Uniprot IDs
P08047
A0A994J5B8
H0Y459
O75376
Q6PGR4
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
6PV0
6PV1
6PV2
6PV3
6UCO
6UCP
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
6WMQ
6WMS
6XXS
6XYX
6XZZ
6Y17
6ZBU
8AS9
8D8I
8DKN
8DKV
8FHE
8FHG
8FKC
8FKD
8FKE
8FKF
8FKG
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleoplasm
Chromatin
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Metabolic Process
DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Cis-regulatory Region Binding
Sequence-specific Double-stranded DNA Binding
Regulation Of MiRNA Metabolic Process
DNA-templated Transcription
Regulation Of MiRNA Transcription
Regulation Of Developmental Process
Chromatin Binding
Regulation Of Multicellular Organismal Process
Regulation Of Cell Population Proliferation
Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Nuclear Receptor Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Receptor-mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Regulation Of Metabolic Process
Nucleus
Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
DNA-templated Transcription
Chromatin
Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Receptor Signaling Pathway
Transcription Repressor Complex
Cell Differentiation
Transcription Corepressor Activity
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Cellular Developmental Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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