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SP1 and EP300
Number of citations of the paper that reports this interaction (PMID
10362258
)
23
Data Source:
HPRD
(in vivo, in vitro)
SP1
EP300
Gene Name
Sp1 transcription factor
E1A binding protein p300
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-DNA Complex
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Enhancer Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
HMG Box Domain Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Transferase Activity, Transferring Acyl Groups
Chromatin DNA Binding
Activating Transcription Factor Binding
Nuclear Hormone Receptor Binding
Androgen Receptor Binding
Pre-mRNA Intronic Binding
Biological Process
Ossification
Trophectodermal Cell Differentiation
Liver Development
Embryonic Placenta Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Viral Process
Megakaryocyte Differentiation
Lung Development
Enucleate Erythrocyte Differentiation
Positive Regulation By Host Of Viral Transcription
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Embryonic Camera-type Eye Morphogenesis
Embryonic Skeletal System Development
Embryonic Process Involved In Female Pregnancy
Definitive Hemopoiesis
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Response To Hypoxia
Somitogenesis
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Internal Protein Amino Acid Acetylation
Apoptotic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Notch Signaling Pathway
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Circadian Rhythm
Organ Morphogenesis
Viral Process
N-terminal Peptidyl-lysine Acetylation
Internal Peptidyl-lysine Acetylation
Lung Development
Positive Regulation Of Protein Binding
Positive Regulation Of Type I Interferon Production
Cellular Response To Heat
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Stabilization
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Regulation Of Tubulin Deacetylation
Regulation Of Cellular Response To Heat
Pathways
Loss of Function of TGFBR2 in Cancer
PPARA activates gene expression
Metabolism of lipids and lipoproteins
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Oncogene Induced Senescence
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMAD4 MH2 Domain Mutants in Cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Metabolism of lipids and lipoproteins
Signaling by Wnt
NOTCH2 intracellular domain regulates transcription
Regulation of gene expression by Hypoxia-inducible Factor
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH2
Pre-NOTCH Transcription and Translation
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1 in Cancer
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
Factors involved in megakaryocyte development and platelet production
Chromatin modifying enzymes
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Mitotic G2-G2/M phases
Constitutive Signaling by NOTCH1 PEST Domain Mutants
PPARA activates gene expression
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Attenuation phase
G2/M Transition
HATs acetylate histones
RORA activates circadian gene expression
HSF1-dependent transactivation
TRAF3-dependent IRF activation pathway
Signaling by NOTCH1
Transcriptional regulation of white adipocyte differentiation
XAV939 inhibits tankyrase, stabilizing AXIN
Pre-NOTCH Expression and Processing
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Innate Immune System
Fatty acid, triacylglycerol, and ketone body metabolism
Cytosolic sensors of pathogen-associated DNA
Cellular response to heat stress
REV-ERBA represses gene expression
Cell Cycle, Mitotic
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
NOTCH1 Intracellular Domain Regulates Transcription
TCF dependent signaling in response to WNT
TRAF6 mediated IRF7 activation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Signaling by WNT in cancer
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Polo-like kinase mediated events
Drugs
Diseases
GWAS
Crohn's disease (
22936669
)
Protein-Protein Interactions
139 interactors:
AATF
AHR
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
BTRC
C3orf17
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RNF4
RXRA
SENP6
SF3A1
SHC1
SKIV2L2
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO1
TAF4
TAL1
TBP
TFAP2A
TLX3
TP53
TPI1
USP39
VHL
YY1
ZBTB16
ZBTB7A
344 interactors:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALX1
APEX1
AR
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF5
ATR
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDK1
CDK2
CDKN1A
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLOCK
CLTC
CNOT4
CNTN2
COPS2
COPS6
CREB1
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
E2F5
EGR1
EID1
EID2
ELF3
ELK1
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO1
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HERC1
HIF1A
HIPK2
HIST1H1A
HIST1H1D
HIST1H2AB
HIST1H2BB
HIST1H3A
HIST1H4A
HIST2H2AB
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HIST4H4
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCM3AP
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MGMT
MITF
MN1
MPG
MRE11A
MSH6
MSTO1
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFKB1
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR2F2
NR4A1
NUP98
NUPR1
NUTM1
OLIG2
PAK2
PAX5
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRKCA
PRKCB
PRKCD
PROX1
PTMA
RAD23A
RAD50
RAN
RB1
RBM14
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
SATB1
SAV1
SENP3
SEPP1
SERTAD1
SET
SETD1A
SGCG
SIRT1
SIRT2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNIP1
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SRC
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBE2D1
UBE2I
UBQLN1
USF2
VPS18
WDR59
WDR82
XRCC6
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF148
ZNF76
ZRANB2
Entrez ID
6667
2033
HPRD ID
01796
04078
Ensembl ID
ENSG00000185591
ENSG00000100393
Uniprot IDs
E4Z9M7
G5E9M8
P08047
Q09472
Q7Z6C1
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
1L3E
1P4Q
2K8F
3BIY
3I3J
3IO2
3P57
3T92
4BHW
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Proliferation
Cellular Response To Organic Substance
Response To Organic Substance
Organ Development
Developmental Process
Multicellular Organismal Development
Anatomical Structure Development
Cellular Metabolic Process
System Development
Regulation Of Cellular Process
Regulation Of Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Response To Hormone
Response To Lipid
Tissue Development
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Response To Organic Substance
Cell Differentiation
Regulation Of Cell Differentiation
Developmental Process
Regulation Of Cell Proliferation
Anatomical Structure Development
Multicellular Organismal Development
Cellular Response To Organic Substance
System Development
Cellular Response To Stress
Response To Stress
Regulation Of Cellular Process
Tissue Development
Tagcloud
?
ache
ahr
antimirs
arguing
cholinergic
cns
correlates
creb
detrusor
influences
jarid1a
limits
mecp2
micrornas
mimics
mir
mirna
mirnas
nuclei
obstruction
outlet
outside
plasticity
pnkd
referenced
synapse
transfection
unrelated
urethra
Tagcloud (Difference)
?
ache
ahr
antimirs
arguing
cholinergic
cns
correlates
creb
detrusor
influences
jarid1a
limits
mecp2
micrornas
mimics
mir
mirna
mirnas
nuclei
obstruction
outlet
outside
plasticity
pnkd
referenced
synapse
transfection
unrelated
urethra
Tagcloud (Intersection)
?