SP1 and ESR1

Number of citations of the paper that reports this interaction (PMID 10446910)
33

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SP1	ESR1
Gene Name		Sp1 transcription factor	estrogen receptor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Transcriptionally Active Chromatin
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Enhancer Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding HMG Box Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Estrogen Receptor Activity Estrogen Response Element Binding Estrogen-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Identical Protein Binding
	Biological Process	Ossification Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Megakaryocyte Differentiation Lung Development Enucleate Erythrocyte Differentiation Positive Regulation By Host Of Viral Transcription Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Antral Ovarian Follicle Growth Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Androgen Metabolic Process Male Gonad Development Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Response To Estradiol Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Cellular Response To Estradiol Stimulus
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Metabolism of lipids and lipoproteins Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) SMAD4 MH2 Domain Mutants in Cancer	Nuclear signaling by ERBB4 Generic Transcription Pathway Nuclear Receptor transcription pathway Signaling by ERBB4
Drugs			Diethylstilbestrol Chlorotrianisene Conjugated Estrogens Etonogestrel Desogestrel Levonorgestrel Progesterone Raloxifene Toremifene Medroxyprogesterone Estrone Tamoxifen Estradiol Ethynodiol Diacetate Clomifene Dienestrol Fulvestrant Norgestimate Ethinyl Estradiol Melatonin Trilostane Naloxone Fluoxymesterone Estramustine Mestranol Danazol Allylestrenol Genistein Compound 19 Compound 18 Compound 4-D 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Estriol Estropipate Quinestrol Ospemifene 17-METHYL-17-ALPHA-DIHYDROEQUILENIN 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL RALOXIFENE CORE
Diseases
GWAS			Alcohol dependence ( 19581569) Bone mineral density ( 23437003) Bone mineral density (hip) ( 19079262 19801982 18445777) Bone mineral density (spine) ( 19079262 19801982 18445777) Breast cancer ( 22383897 21263130 19219042 23535729 23535733 20453838) Breast size ( 22747683) Chronic myeloid leukemia ( 21540461) Height ( 20881960 23563607) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		139 interactors: AATF AHR AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 BTRC C3orf17 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RNF4 RXRA SENP6 SF3A1 SHC1 SKIV2L2 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO1 TAF4 TAL1 TBP TFAP2A TLX3 TP53 TPI1 USP39 VHL YY1 ZBTB16 ZBTB7A	266 interactors: ACTN4 AHR AKAP13 AKT1 AKT2 AR ARHGEF15 ARNT ATAD2 BAG1 BCAR1 BCAS2 BDNF BRCA1 BTF3 CALM1 CALM2 CALM3 CAV1 CBLL1 CCNC CCND1 CCNH CCNT1 CDC25B CDK2 CDK7 CDK8 CDKN1A CEBPA CEBPB CHD9 CHUK CITED1 COPS5 CREBBP CSNK2B CTNNB1 CUEDC2 CUL4B DAP3 DDX5 DDX54 DNTTIP2 DUT EGFR EHMT2 EIF3I EP300 ERBB2 ESR2 ESRRA FHL2 FKBP4 FKBP5 FLII FOXO1 FOXO3 FOXO4 GADD45B GADD45G GNAI1 GNAI2 GNAI3 GRB2 GRIP1 GTF2B GTF2H1 HDAC4 HDAC5 HDAC9 HEXIM1 HNF4A HSP90AA1 HSP90AB1 HSPA4 HSPA8 IGF1R ING1 ISL1 ITGB3BP JUN JUNB JUND KAT5 KDM5A KIF1A KLF5 KMT2D LCK LCOR LDB1 LINC00312 LRIF1 MAPK1 MAPK14 MAPK3 MDM2 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED25 MED6 MED7 MEN1 MGMT MKNK2 MMS19 MNAT1 MPG MSH2 MTA1 MTA2 MTA3 MTCH2 MUC1 MVP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOA7 NCOR1 NCOR2 NELFB NFKB1 NPPA NR0B1 NR0B2 NR1H4 NR2C1 NR2C2 NR2F1 NR2F6 NRIP1 NSD1 OTUB1 PAGR1 PAK1 PAK6 PELP1 PGC PGR PHB PHB2 PIAS1 PIAS2 PIAS3 PIK3R1 PIK3R3 PNRC2 POLR1B POLR2D POU2F1 POU2F2 POU4F1 POU4F2 PPARG PPARGC1A PPARGC1B PPID PRDM2 PRKACA PRMT1 PRMT2 PRPF6 PSMC5 PTEN PTGES3 PTMA PTPN1 PTPN6 RAC3 RANBP9 RARA RBBP4 RBBP7 RBFOX2 RBM23 RBM39 RELA REXO4 RFX4 RGS3 RLIM RNF14 RNF4 RPS6KA1 RPS6KA3 RXRA SAFB SAFB2 SETD7 SF1 SHC1 SKIL SKP2 SLC30A9 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCD3 SMARCE1 SMURF1 SMYD2 SOS1 SP1 SP3 SRA1 SRC SREBF1 STAT5A STRN STUB1 SUMO1 SUV39H1 SUV420H1 SVIL TAB2 TADA3 TAF10 TAF1A TAF1B TAF2 TAP1 TBP TCF20 TDG THRA THRB TNFRSF14 TP53 TRAM1 TRIM24 TRIM25 TRIM28 TRIM59 TRIP4 TRRAP TSC2 TUBA1B TUBB UBE2I UIMC1 USF1 VAV3 WHSC1 WIPI1 XBP1 YWHAH YWHAQ ZBTB16 ZBTB17 ZNF398
Entrez ID		6667	2099
HPRD ID		01796	00589
Ensembl ID		ENSG00000185591	ENSG00000091831
Uniprot IDs		E4Z9M7 G5E9M8 P08047	G4XH65 P03372 Q9UBT1
PDB IDs		1SP1 1SP2 1VA1 1VA2 1VA3	1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3Q97 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Cellular Response To Organic Substance Response To Organic Substance Organ Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Cellular Metabolic Process System Development Regulation Of Cellular Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Response To Lipid Tissue Development	Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Response To Hormone Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cellular Response To Hormone Stimulus Androgen Receptor Signaling Pathway Signal Transduction Response To Stimulus Developmental Process
Tagcloud ?			analyzing brca1 carcinogenic changed characters coactivator concordant conduct differentiationassociated discovered downloaded e2 enrichment estradiol go gses9623 gsm986085 gsm986087 guidance macs mcf7 omnibus ontology p300bound p300regulated participated peakcalling software theoretical
Tagcloud (Difference) ?			analyzing brca1 carcinogenic changed characters coactivator concordant conduct differentiationassociated discovered downloaded e2 enrichment estradiol go gses9623 gsm986085 gsm986087 guidance macs mcf7 omnibus ontology p300bound p300regulated participated peakcalling software theoretical
Tagcloud (Intersection) ?