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SP1 and HOXC11
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
SP1
HOXC11
Gene Name
Sp1 transcription factor
homeobox C11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-DNA Complex
Nucleoplasm
Cytoplasm
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Enhancer Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
HMG Box Domain Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Biological Process
Ossification
Trophectodermal Cell Differentiation
Liver Development
Embryonic Placenta Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Viral Process
Megakaryocyte Differentiation
Lung Development
Enucleate Erythrocyte Differentiation
Positive Regulation By Host Of Viral Transcription
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Embryonic Camera-type Eye Morphogenesis
Embryonic Skeletal System Development
Embryonic Process Involved In Female Pregnancy
Definitive Hemopoiesis
Metanephros Development
Organ Induction
Transcription, DNA-templated
Endoderm Development
Anterior/posterior Pattern Specification
Proximal/distal Pattern Formation
Embryonic Digit Morphogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Skeletal Joint Morphogenesis
Pathways
Loss of Function of TGFBR2 in Cancer
PPARA activates gene expression
Metabolism of lipids and lipoproteins
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Oncogene Induced Senescence
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
139 interactors:
AATF
AHR
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
BTRC
C3orf17
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RNF4
RXRA
SENP6
SF3A1
SHC1
SKIV2L2
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO1
TAF4
TAL1
TBP
TFAP2A
TLX3
TP53
TPI1
USP39
VHL
YY1
ZBTB16
ZBTB7A
12 interactors:
CD2AP
GTF2A1L
GTF2H1
HDAC5
HTT
IRF4
MEIS1
SMAD3
SOX8
SP1
STAT3
TBX21
Entrez ID
6667
3227
HPRD ID
01796
09275
Ensembl ID
ENSG00000185591
ENSG00000123388
Uniprot IDs
E4Z9M7
G5E9M8
P08047
O43248
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Proliferation
Cellular Response To Organic Substance
Response To Organic Substance
Organ Development
Developmental Process
Multicellular Organismal Development
Anatomical Structure Development
Cellular Metabolic Process
System Development
Regulation Of Cellular Process
Regulation Of Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Response To Hormone
Response To Lipid
Tissue Development
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
RNA Biosynthetic Process
RNA Metabolic Process
Positive Regulation Of Metabolic Process
Gene Expression
Heterocycle Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Immune System Development
Negative Regulation Of Cell Differentiation
Eye Development
Eye Morphogenesis
Nitrogen Compound Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Organ Development
Regulation Of Cell Development
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Mesenchyme Development
Regulation Of RNA Metabolic Process
Regulation Of Cell Differentiation
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Initiation
Cell Differentiation
Organ Morphogenesis
Cellular Aromatic Compound Metabolic Process
Sensory Organ Development
Regulation Of Nitrogen Compound Metabolic Process
Ossification
Hemopoiesis
Negative Regulation Of Neurogenesis
Cellular Response To Organic Substance
Negative Regulation Of Cell Development
Paraxial Mesoderm Morphogenesis
System Development
Camera-type Eye Development
Regulation Of Metabolic Process
Camera-type Eye Morphogenesis
Tagcloud
?
absent
akt1
colinearly
demethylating
evolutionarily
fibroblast
h3k27me3
h3k9
hdac
hdac6
hoxc5
hoxd10
interacted
kdm6b
mark
mef
organized
patterning
posterior
reagent
repressed
silico
specify
synergistically
tss
turned
Tagcloud (Difference)
?
absent
akt1
colinearly
demethylating
evolutionarily
fibroblast
h3k27me3
h3k9
hdac
hdac6
hoxc5
hoxd10
interacted
kdm6b
mark
mef
organized
patterning
posterior
reagent
repressed
silico
specify
synergistically
tss
turned
Tagcloud (Intersection)
?