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SP1 and HIF1A
Number of citations of the paper that reports this interaction (PubMedID
17024177
)
63
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo)
SP1
HIF1A
Description
Sp1 transcription factor
hypoxia inducible factor 1 subunit alpha
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Protein-DNA Complex
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Metal Ion Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Receptor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Hsp90 Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
Transcription Regulator Activator Activity
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Cellular Response To Insulin Stimulus
Response To Hydroperoxide
Cellular Response To Zinc Ion Starvation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Host-mediated Activation Of Viral Transcription
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Cellular Response To Estrogen Stimulus
Positive Regulation Of Amyloid-beta Formation
Cellular Response To Wortmannin
Positive Regulation Of Hydrogen Sulfide Biosynthetic Process
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
Response To Reactive Oxygen Species
Angiogenesis
Blood Vessel Development
Response To Hypoxia
Intracellular Glucose Homeostasis
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Chondrocyte Differentiation
Glandular Epithelial Cell Differentiation
Glandular Epithelial Cell Maturation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Apoptotic Process
Signal Transduction
Neuroblast Proliferation
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Bone Mineralization
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
TOR Signaling
Negative Regulation Of TOR Signaling
Intracellular Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Cellular Response To Oxidative Stress
Embryonic Hemopoiesis
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Cell Population Proliferation
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Blood Vessel Morphogenesis
Digestive Tract Morphogenesis
Camera-type Eye Morphogenesis
Cartilage Development
Neuron Apoptotic Process
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of Chemokine-mediated Signaling Pathway
Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Mesenchymal Cell Apoptotic Process
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Nitric Oxide Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Regulation of CDH11 gene transcription
Regulation of CDH11 gene transcription
Positive Regulation of CDH1 Gene Transcription
NFE2L2 regulating tumorigenic genes
TGFBR3 expression
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
STAT3 nuclear events downstream of ALK signaling
Regulation of PD-L1(CD274) transcription
Drugs
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Vadadustat
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Hypospadias (moderate to severe) (
31856834
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil percentage of white cells (
27863252
)
Parkinsonism in frontotemporal lobe dementia (
29724592
)
Percentage gas trapping (
26030696
)
Progressive supranuclear palsy (
30089514
)
Red blood cell count (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
149 interacting genes:
AATF
AHR
AKT1
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
CTCFL
CTNNB1
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KAT2B
KIF1A
KLF10
KLF4
KLF6
LDB1
LINC00955
LMO2
MAP1LC3A
MAPK1
MAPK3
MAPK8
MBD1
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MTREX
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NPM1
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RMP64
RNF4
RORA
RXRA
SENP6
SF3A1
SHC1
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO2
TAF4
TAL1
TBP
TLX3
TP53
TP73
TPI1
VEGFA
VHL
YY1
ZBTB16
ZBTB2
ZBTB5
ZBTB7A
133 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ATM
AURKA
BAP1
BMAL1
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CHD4
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FBXL16
FBXO8
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
L3MBTL3
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PPP1R13L
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SNHG11
SP1
SSX4
STAT3
STK11
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
UBE3B
USP19
USP20
USP28
VBP1
VEGFA
VHL
VHLL
VRK1
ZC3H12A
Entrez ID
6667
3091
HPRD ID
01796
04517
Ensembl ID
ENSG00000185591
ENSG00000100644
Uniprot IDs
P08047
D0VY79
Q16665
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
6PV0
6PV1
6PV2
6PV3
6UCO
6UCP
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
6YW3
7LVS
7QGS
8HE0
8HE3
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleoplasm
Chromatin
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Metabolic Process
DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Cis-regulatory Region Binding
Sequence-specific Double-stranded DNA Binding
Regulation Of MiRNA Metabolic Process
DNA-templated Transcription
Regulation Of MiRNA Transcription
Regulation Of Developmental Process
Chromatin Binding
Regulation Of Multicellular Organismal Process
Regulation Of Cell Population Proliferation
Cis-regulatory Region Sequence-specific DNA Binding
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Intracellular Signal Transduction
Chromatin
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Oxygen Levels
Response To Stress
Response To Decreased Oxygen Levels
Regulation Of Cell Cycle
Response To Hypoxia
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Tagcloud
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Tagcloud (Intersection)
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