SP1 and SRF

Number of citations of the paper that reports this interaction (PubMedID 10082523)
42

Data Source:
BioGRID (pull down)

		SP1	SRF
Description		Sp1 transcription factor	serum response factor
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Cellular Response To Zinc Ion Starvation Positive Regulation Of Blood Vessel Endothelial Cell Migration Host-mediated Activation Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estrogen Stimulus Positive Regulation Of Amyloid-beta Formation Cellular Response To Wortmannin Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription
Pathways		PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression SARS-CoV-1 targets host intracellular signalling and regulatory pathways Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Positive Regulation of CDH1 Gene Transcription NFE2L2 regulating tumorigenic genes TGFBR3 expression	RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		149 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KAT2B KIF1A KLF10 KLF4 KLF6 LDB1 LINC00955 LMO2 MAP1LC3A MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RMP64 RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB5 ZBTB7A	71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3
Entrez ID		6667	6722
HPRD ID		01796	02788
Ensembl ID		ENSG00000185591	ENSG00000112658
Uniprot IDs		P08047	B4DU24 P11831
PDB IDs		1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP	1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Sequence-specific Double-stranded DNA Binding Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of MiRNA Transcription Regulation Of Developmental Process Chromatin Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?