SNCB and GRK6

Number of citations of the paper that reports this interaction (PMID 10852916)
68

Data Source:
BioGRID (enzymatic study)

		SNCB	GRK6
Gene Name		synuclein, beta	G protein-coupled receptor kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Inclusion Body Growth Cone Neuronal Cell Body Terminal Bouton	Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Alpha-tubulin Binding Beta-tubulin Binding	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding
	Biological Process	Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synapse Organization	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		11 interactors: APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 PLK1 PLK3 SEPT4 SNCA	18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R
Entrez ID		6620	2870
HPRD ID		03980	02925
Ensembl ID		ENSG00000074317	ENSG00000198055
Uniprot IDs		G4Y815 G4Y816 Q16143	P43250
PDB IDs			2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phosphorylation Positive Regulation Of Proteolysis Protein Phosphorylation Response To Oxidative Stress Regulation Of Protein Stability Posttranscriptional Regulation Of Gene Expression Apoptotic Process Programmed Cell Death Protein Destabilization Cell Death Death Regulation Of Signal Transduction Protein Metabolic Process Negative Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Processing	G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress
Tagcloud ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Difference) ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Intersection) ?