SNCB and GRK1

Number of citations of the paper that reports this interaction (PMID 10852916)
68

Data Source:
BioGRID (enzymatic study)

		SNCB	GRK1
Gene Name		synuclein, beta	G protein-coupled receptor kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Inclusion Body Growth Cone Neuronal Cell Body Terminal Bouton	Photoreceptor Disc Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity
	Biological Process	Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synapse Organization	Visual Perception Phototransduction, Visible Light Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Photoreceptor Cell Morphogenesis Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Protein Autophosphorylation Post-embryonic Retina Morphogenesis In Camera-type Eye
Pathways			Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 PLK1 PLK3 SEPT4 SNCA	8 interactors: CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG
Entrez ID		6620	6011
HPRD ID		03980	01585
Ensembl ID		ENSG00000074317
Uniprot IDs		G4Y815 G4Y816 Q16143	Q15835
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phosphorylation Positive Regulation Of Proteolysis Protein Phosphorylation Response To Oxidative Stress Regulation Of Protein Stability Posttranscriptional Regulation Of Gene Expression Apoptotic Process Programmed Cell Death Protein Destabilization Cell Death Death Regulation Of Signal Transduction Protein Metabolic Process Negative Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Processing	Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Oxidoreductase Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Detection Of Visible Light Positive Regulation Of Calcium Ion Transport Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Ion Transport Detection Of Light Stimulus Negative Regulation Of Monooxygenase Activity Response To Abiotic Stimulus Response To Inorganic Substance Cellular Response To Radiation Regulation Of Ion Homeostasis Regulation Of Dopamine Secretion Synapse Organization Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Synaptic Transmission Regulation Of Catalytic Activity Negative Regulation Of Oxidoreductase Activity Positive Regulation Of Ion Transport Dopamine Metabolic Process Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Transporter Activity Catecholamine Metabolic Process Receptor Internalization Positive Regulation Of Lyase Activity Regulation Of Signaling Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Organic Cyclic Compound Response To External Stimulus Negative Regulation Of Protein Phosphorylation Cell-cell Signaling Response To Metal Ion Negative Regulation Of Transmembrane Transport Response To Light Stimulus
Tagcloud ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?