SNCB and GRK5

Number of citations of the paper that reports this interaction (PMID 10852916)
68

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SNCB	GRK5
Gene Name		synuclein, beta	G protein-coupled receptor kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Inclusion Body Growth Cone Neuronal Cell Body Terminal Bouton	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding
	Biological Process	Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synapse Organization	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		11 interactors: APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 PLK1 PLK3 SEPT4 SNCA	19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6620	2869
HPRD ID		03980	02926
Ensembl ID		ENSG00000074317	ENSG00000198873
Uniprot IDs		G4Y815 G4Y816 Q16143	P34947
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phosphorylation Positive Regulation Of Proteolysis Protein Phosphorylation Response To Oxidative Stress Regulation Of Protein Stability Posttranscriptional Regulation Of Gene Expression Apoptotic Process Programmed Cell Death Protein Destabilization Cell Death Death Regulation Of Signal Transduction Protein Metabolic Process Negative Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Processing	Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport
Tagcloud ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?