SUMO2 and AURKB

Number of citations of the paper that reports this interaction (PMID 20663916)
17

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SUMO2	AURKB
Gene Name		small ubiquitin-like modifier 2	aurora kinase B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5	48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1
Entrez ID		6613	9212
HPRD ID		04332	05397
Ensembl ID		ENSG00000188612	ENSG00000178999
Uniprot IDs		P61956	Q96GD4
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO	4AF3
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress	Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?