SUMO2 and USPL1

Number of citations of the paper that reports this interaction (PMID 22878415)
10

Data Source:
BioGRID (enzymatic study)

		SUMO2	USPL1
Gene Name		small ubiquitin-like modifier 2	ubiquitin specific peptidase like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Extracellular Space Cajal Body
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Binding SUMO Binding Ubiquitin Binding SUMO-specific Isopeptidase Activity
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Proteolysis Cell Proliferation Protein Desumoylation Cajal Body Organization
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5	5 interactors: RANGAP1 SP100 SUMO1 SUMO2 SUMO3
Entrez ID		6613	10208
HPRD ID		04332	09833
Ensembl ID		ENSG00000188612	ENSG00000132952
Uniprot IDs		P61956	A8K1B1 Q5W0Q7
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress	Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Peptidyl-lysine Modification Regulation Of Protein Export From Nucleus Positive Regulation Of Proteolysis Negative Regulation Of DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Binding Negative Regulation Of Intracellular Protein Transport Protein Modification By Small Protein Conjugation Negative Regulation Of Binding Regulation Of Proteolysis Negative Regulation Of Intracellular Transport Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Interferon-gamma Regulation Of Fas Signaling Pathway Response To Interferon-gamma Protein Localization To Nucleus Negative Regulation Of Protein Transport Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport PML Body Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Binding Protein Localization To Nuclear Pore Positive Regulation Of Ran GTPase Activity Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Metabolic Process Protein Localization To Nuclear Envelope Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transport DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Metabolic Process Regulation Of Intracellular Transport Cytokine-mediated Signaling Pathway Protein Localization To Organelle Regulation Of Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Intersection) ?