SUMO2 and CHAF1A

Number of citations of the paper that reports this interaction (PMID 19471022)
89

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		SUMO2	CHAF1A
Gene Name		small ubiquitin-like modifier 2	chromatin assembly factor 1, subunit A (p150)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Nuclear Chromatin CAF-1 Complex Protein Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	DNA Replication DNA Repair DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Cycle Chromatin Assembly
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5	37 interactors: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B DBF4 DDX41 HIST1H3E HIST3H3 HMGB2 LZTR1 MBD1 MSH6 PABPC1 PCBD2 PCNA RBFOX2 REL SET SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408
Entrez ID		6613	10036
HPRD ID		04332	03148
Ensembl ID		ENSG00000188612	ENSG00000167670
Uniprot IDs		P61956	Q13111
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Protein-DNA Complex Assembly Chromosome Organization Nitrogen Compound Metabolic Process Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Chromatin Assembly Nucleosome Organization Cellular Response To DNA Damage Stimulus Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process DNA Packaging Positive Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Sumoylation DNA Recombination Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Telomere Maintenance Organelle Organization DNA Replication Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Protein Complex Assembly Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst
Tagcloud (Intersection) ?