SUMO2 and SENP1

Number of citations of the paper that reports this interaction (PMID 22878415)
10

Data Source:
BioGRID (enzymatic study)

		SUMO2	SENP1
Gene Name		small ubiquitin-like modifier 2	SUMO1/sentrin specific peptidase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Signaling Pathway
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5	15 interactors: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 PARP1 RABGAP1 RANBP2 RANGAP1 SP100 SUMO1 SUMO2 SUMO3 USP25
Entrez ID		6613	29843
HPRD ID		04332	07153
Ensembl ID		ENSG00000188612	ENSG00000079387
Uniprot IDs		P61956	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress	Protein Sumoylation Positive Regulation Of Metabolic Process Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Regulation Of Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis PML Body Organization Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Protein Modification Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Nucleus Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Viral Transcription Regulation Of Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Homeostatic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Binding Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Protein Metabolic Process Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Response To Organic Substance
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn	20a 5p alteration biopsies carcinogenesis ccr coli colibactin colonized consequence crc escherichia genotoxic gut harbors involve island microbiota mucosa paradigm pks producing promote senescence sumoylation suspected sustained uninfected xenograft
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