DMPK and PLN

Number of citations of the paper that reports this interaction (PubMedID 15598648)
0

Data Source:
HPRD (in vitro, in vivo)

		DMPK	PLN
Description		DM1 protein kinase	phospholamban
Image
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Nuclear Membrane Mitochondrial Membrane Sarcoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex Phospholamban Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding ATPase Binding Transporter Inhibitor Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Intracellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Regulation Of Synapse Structural Plasticity	Acrosome Assembly Regulation Of The Force Of Heart Contraction Calcium Ion Transport Intracellular Calcium Ion Homeostasis Notch Signaling Pathway Spermatogenesis Blood Circulation Regulation Of Heart Contraction Visual Learning Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Insulin Response To Testosterone Locomotor Rhythm Negative Regulation Of Heart Contraction Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Circadian Sleep/wake Cycle, Sleep Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion homeostasis	Ion homeostasis Ion transport by P-type ATPases
Drugs		Bisindolylmaleimide VIII
Diseases		Myotonic dystrophy (DM)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)	Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 19305408 19305409 19587794 23166209 24952745 29874175) Resting heart rate ( 27798624)
Interacting Genes		19 interacting genes: ANXA7 ATN1 ATXN1 CDC73 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	68 interacting genes: AQP6 ARL13B ARLN ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELN ELOVL4 ERGIC3 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35H1 SLC39A2 SLC61A1 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2
Entrez ID		1760	5350
HPRD ID		05645	01395
Ensembl ID		ENSG00000104936	ENSG00000198523
Uniprot IDs		B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013	P26678 Q5R352
PDB IDs		1WT6 2VD5	1PLP 1ZLL 2HYN 6Y40 7E0Z 7E11 7E12
Enriched GO Terms of Interacting Partners?		Regulation Of Cardiac Muscle Cell Membrane Potential G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein-containing Complex Organization SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Motor Neuron Axon Guidance Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Developmental Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Rhombomere 3 Morphogenesis Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Cis-trans Isomerase Activity Cellular Component Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Protein Glutathionylation Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Insulin-like Growth Factor Receptor Signaling Pathway Spliceosomal SnRNP Assembly Response To Lipid Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Rhombomere 2 Development Positive Regulation Of Transcription By RNA Polymerase II Cytosol Enzyme Inhibitor Activity Focal Adhesion Regulation Of Biological Quality Positive Regulation Of Protein Phosphorylation Visual Behavior Regulation Of The Force Of Heart Contraction By Cardiac Conduction Visual Learning Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade	Membrane Endoplasmic Reticulum Membrane Protein Binding Sarcoplasmic Reticulum Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Import Into Sarcoplasmic Reticulum Glutathione Peroxidase Activity Leukotriene-C4 Synthase Activity Regulation Of Cardiac Conduction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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