DMPK and RPS10

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DMPK	RPS10
Description		DM1 protein kinase	ribosomal protein S10
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GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Nuclear Membrane Mitochondrial Membrane Sarcoplasmic Reticulum Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Intracellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Regulation Of Synapse Structural Plasticity	Cytoplasmic Translation Translation
Pathways		Ion homeostasis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Bisindolylmaleimide VIII
Diseases		Myotonic dystrophy (DM)	Diamond-Blackfan anemia (DBA)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)	Adult body size ( 32376654) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate ( 30604766 31015462) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494)
Interacting Genes		19 interacting genes: ANXA7 ATN1 ATXN1 CDC73 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	19 interacting genes: APP DMPK DNMT3B DUX4 DVL3 EED FBXO25 HAP1 HIP1 KAT7 MKRN1 PFN2 PTTG1 RNF10 SYK TCF25 WIZ XRCC6 ZNF598
Entrez ID		1760	6204
HPRD ID		05645	04697
Ensembl ID		ENSG00000104936	ENSG00000124614
Uniprot IDs		B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013	P46783
PDB IDs		1WT6 2VD5	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Regulation Of Cardiac Muscle Cell Membrane Potential G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein-containing Complex Organization SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Motor Neuron Axon Guidance Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Developmental Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Rhombomere 3 Morphogenesis Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Cis-trans Isomerase Activity Cellular Component Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Protein Glutathionylation Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Insulin-like Growth Factor Receptor Signaling Pathway Spliceosomal SnRNP Assembly Response To Lipid Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Rhombomere 2 Development Positive Regulation Of Transcription By RNA Polymerase II Cytosol Enzyme Inhibitor Activity Focal Adhesion Regulation Of Biological Quality Positive Regulation Of Protein Phosphorylation Visual Behavior Regulation Of The Force Of Heart Contraction By Cardiac Conduction Visual Learning Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade	Presynapse Regulation Of Superoxide Anion Generation Regulation Of Primary Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Regulation Of Receptor Internalization Nucleus Positive Regulation Of Superoxide Anion Generation Protein Stabilization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nervous System Process Regulation Of Receptor-mediated Endocytosis Molecular Function Activator Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Calcium-mediated Signaling Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Superoxide Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Receptor Internalization Cytoplasm Frizzled Binding Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Regulation Of Protein Stability Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of ERBB Signaling Pathway Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Positive Regulation Of Neurotrophin Production Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Positive Regulation Of DNA Replication Rescue Of Stalled Ribosome Ribosome Disassembly
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