BMPR1B and BMP4

Number of citations of the paper that reports this interaction (PubMedID 11282024)
0

Data Source:
HPRD (in vitro)

		BMPR1B	BMP4
Description		bone morphogenetic protein receptor type 1B	bone morphogenetic protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity Protein Serine/threonine Kinase Activator Activity BMP Receptor Binding
	Biological Process	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Blood Vessel Development Osteoblast Differentiation Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Mesoderm Formation Organ Induction Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Renal System Process Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Sinoatrial Node Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Transcription By RNA Polymerase II Germ Cell Development Endoderm Development Mesoderm Development Mesodermal Cell Fate Determination Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Cell Differentiation Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Ameloblast Differentiation Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Inner Ear Auditory Receptor Cell Differentiation Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Mesodermal Cell Differentiation Intermediate Mesodermal Cell Differentiation Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Smooth Muscle Tissue Development Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Bone Development Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lung Morphogenesis Lung Vasculature Development Epithelium Development Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Prostate Gland Morphogenesis Prostatic Bud Formation Muscle Tissue Development Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Coronary Vasculature Development Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Ureter Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Pericyte Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Primary MiRNA Processing Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BMP	Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Germ layer formation at gastrulation Formation of lateral plate mesoderm Formation of intermediate mesoderm Formation of paraxial mesoderm Specification of primordial germ cells Formation of the nephric duct Formation of the ureteric bud Specification of the neural plate border
Drugs		Fostamatinib	Calcium
Diseases		Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E	Anophthalmia and microphthalmia (A/M)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30578418 30224653) Waist-hip ratio ( 28552196)	Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chin dimples ( 27182965) Colorectal cancer ( 25990418 26151821 19011631) Colorectal cancer or advanced adenoma ( 30510241) Dental caries ( 23259602) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Logical memory (delayed recall) in normal cognition ( 29274321) Lung function (FEV1/FVC) ( 30804560) Monobrow thickness ( 26926045) Myopia ( 27182965) Optic cup area ( 25631615) Optic disc size ( 31809533) Parkinson's disease ( 19915575) Peak expiratory flow ( 30804560) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 CRIPTO GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TWSG1 ZFYVE9
Entrez ID		658	652
HPRD ID		04457	00207
Ensembl ID		ENSG00000138696	ENSG00000125378
Uniprot IDs		A8KAE3 O00238	P12644 Q53XC5
PDB IDs		3MDY
Enriched GO Terms of Interacting Partners?		Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway BMP Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway BMP Receptor Activity Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Pattern Specification Process Cellular Response To BMP Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Osteoblast Differentiation Regionalization Activin Receptor Signaling Pathway Extracellular Space Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Growth Factor Binding Mesoderm Formation Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Biomineral Tissue Development Osteoblast Differentiation Positive Regulation Of Ossification Cellular Response To Growth Factor Stimulus Formation Of Primary Germ Layer Regulation Of Cell Communication Regulation Of Signaling Dorsal/ventral Pattern Formation Anterior/posterior Pattern Specification Animal Organ Morphogenesis Response To Growth Factor Cellular Developmental Process Cell Differentiation Positive Regulation Of Osteoblast Differentiation Signal Transduction Epithelial Cell Proliferation Developmental Process Regulation Of Bone Mineralization Extracellular Region Activin Receptor Activity, Type II
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