BMPR1B and PPP3CC

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		BMPR1B	PPP3CC
Description		bone morphogenetic protein receptor type 1B	protein phosphatase 3 catalytic subunit gamma
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding
	Biological Process	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Protein Dephosphorylation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Signaling by BMP	Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs		Fostamatinib
Diseases		Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30578418 30224653) Waist-hip ratio ( 28552196)	General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	13 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 TGFBR1 THAP7 UNC119
Entrez ID		658	5533
HPRD ID		04457	00236
Ensembl ID		ENSG00000138696	ENSG00000120910
Uniprot IDs		A8KAE3 O00238	P48454
PDB IDs		3MDY	7U0T
Enriched GO Terms of Interacting Partners?		Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration	Regulation Of Extrinsic Apoptotic Signaling Pathway Heparan Sulfate Binding Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Cytoplasmic Vesicle Synapse Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Cell Projection Morphogenesis Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import System Development Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Positive Regulation Of Calcium-mediated Signaling Regulation Of Signal Transduction Regulation Of Multicellular Organism Growth Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Lipoprotein Particle Positive Regulation Of Cell Differentiation Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway
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