BMPR1B and RAB6B

Number of citations: 0 (PubMedID 15761153)
Data Source: HPRD (in vivo)

		BMPR1B	RAB6B
Name		bone morphogenetic protein receptor type 1B	RAB6B, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Golgi Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Protein Localization To Golgi Membrane
Pathways		Signaling by BMP	COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Fostamatinib	None
Diseases		Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E	None
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Attention deficit hyperactivity disorder ( 20732626 ) Colorectal cancer or advanced adenoma ( 30510241 ) Coronary artery disease ( 29212778 33020668 ) Diverticular disease ( 30177863 ) Haemorrhoidal disease ( 33888516 ) Heel bone mineral density ( 30598549 ) Hen's egg allergy ( 29051540 ) Maximum stenosis ( 32469969 ) Opioid dependence (time to event) ( 34124712 ) Polycystic ovary syndrome (reproductive subtype) ( 32574161 ) Prepulse inhibition of the startle response ( 31596458 ) Schizophrenia ( 30470734 ) Sum of carotid plaque area ( 32469969 ) Sum of stenosis ( 32469969 ) Systolic blood pressure ( 30578418 30224653 ) Waist-hip ratio ( 28552196 )	Blood protein levels ( 30072576 ) Immune reponse to smallpox (secreted IL-1beta) ( 22610502 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Mean corpuscular hemoglobin ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )
Interacting Genes		64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	13 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 SH2B2 SMAD1 TGFBR1
Entrez ID		658	51560
HPRD ID		04457	11474
Ensembl ID		ENSG00000138696	ENSG00000154917
Uniprot IDs		A8KAE3 O00238	Q9NRW1
PDB IDs		3MDY	2E9S 2FE4 2FFQ
GO Terms Enriched among Interactors		Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type I SMAD Binding BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Activin Binding BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Response To Growth Factor Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Binding Osteoblast Differentiation Regulation Of Osteoblast Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Cell Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Growth Factor Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Ossification Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Embryonic Heart Tube Morphogenesis Bone Development Homomeric SMAD Protein Complex Phosphomannomutase Activity Vascular Endothelial Cell Proliferation