BMPR1B and BMP15

Number of citations of the paper that reports this interaction (PMID 12419820)
29

Data Source:
HPRD (in vitro)

		BMPR1B	BMP15
Gene Name		bone morphogenetic protein receptor, type IB	bone morphogenetic protein 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Space Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity
	Biological Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Transcription, DNA-templated Cell Development Granulosa Cell Development SMAD Protein Signal Transduction
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732626)
Protein-Protein Interactions		63 interactors: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	2 interactors: BMPR1B GDF9
Entrez ID		658	9210
HPRD ID		04457	02216
Ensembl ID		ENSG00000138696	ENSG00000130385
Uniprot IDs		A8KAE3 O00238	O95972
PDB IDs		3MDY
Enriched GO Terms of Interacting Partners?		Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Signaling Regulation Of Protein Phosphorylation Regulation Of Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Cellular Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Signal Transduction By Phosphorylation Regulation Of Cell Development Regulation Of Cellular Process Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Phosphorylation	BMP Signaling Pathway Oogenesis Female Gamete Generation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Developmental Growth Ovarian Cumulus Expansion Oocyte Growth Negative Regulation Of Chondrocyte Proliferation Regulation Of Progesterone Secretion Growth Oogenesis Stage Antral Ovarian Follicle Growth Gamete Generation Developmental Process Involved In Reproduction Regulation Of Female Gonad Development Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Reproduction Cartilage Condensation Single Organism Reproductive Process Chondrocyte Development Positive Regulation Of Signal Transduction Reproductive Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Regulation Of Apoptotic Process Oocyte Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Pathway-restricted SMAD Protein Phosphorylation Proteoglycan Biosynthetic Process SMAD Protein Signal Transduction Ovarian Follicle Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Endochondral Bone Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Chondrocyte Differentiation Developmental Cell Growth
Tagcloud ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	124a 16c 2039a 351a 397c 538a 538g 769a 769g 788instct 852c 919a 9c accumulative allelic asian asians caucasian cgg cnki esr1 ethnicity fmr1 fshr inception inha pof premutation revman
Tagcloud (Difference) ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	124a 16c 2039a 351a 397c 538a 538g 769a 769g 788instct 852c 919a 9c accumulative allelic asian asians caucasian cgg cnki esr1 ethnicity fmr1 fshr inception inha pof premutation revman
Tagcloud (Intersection) ?