BMPR1B and UBXN1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		BMPR1B	UBXN1
Gene Name		bone morphogenetic protein receptor, type IB	UBX domain protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Proteasome Complex Nucleus Cytoplasm Dendrite Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding	Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732626)
Protein-Protein Interactions		63 interactors: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	15 interactors: ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HOMER2 PLA2G4A PLAA SMAD1 SMURF1 TGFBR1 TRIM39 UBE2I UBQLN1 VCP
Entrez ID		658	51035
HPRD ID		04457	11266
Ensembl ID		ENSG00000138696	ENSG00000162191
Uniprot IDs		A8KAE3 O00238	Q04323
PDB IDs		3MDY
Enriched GO Terms of Interacting Partners?		Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Signaling Regulation Of Protein Phosphorylation Regulation Of Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Cellular Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Signal Transduction By Phosphorylation Regulation Of Cell Development Regulation Of Cellular Process Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Phosphorylation	Regulation Of Apoptotic Process Regulation Of Cell Death BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Ossification Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Osteoblast Differentiation Signal Transduction By Phosphorylation Regulation Of Cartilage Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signaling Positive Regulation Of Cell Death Positive Regulation Of Ossification Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Protein Metabolic Process Pharyngeal System Development Regulation Of Osteoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Postreplication Repair Inflammatory Response Activin Receptor Signaling Pathway Response To Organic Cyclic Compound Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Polyubiquitination Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Pattern Specification Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Cell Cycle Process Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tagcloud ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west
Tagcloud (Difference) ?		125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a	adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west
Tagcloud (Intersection) ?