SLC8A1 and YWHAB

Number of citations of the paper that reports this interaction (PMID 16679322)
5

Data Source:
HPRD (in vitro)

		SLC8A1	YWHAB
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Z Disc T-tubule Sarcolemma	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Embryonic Placenta Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Heart Morphogenesis Ion Transport Cellular Sodium Ion Homeostasis Muscle Contraction Blood Coagulation Post-embryonic Development Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Cellular Response To Reactive Oxygen Species Embryonic Heart Tube Development Response To Muscle Stretch Relaxation Of Smooth Muscle Muscle Fiber Development Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Cellular Response To Caffeine Sodium Ion Export Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis	Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		HIV-associated dementia ( 22628157) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) QT interval ( 22726844)
Protein-Protein Interactions		6 interactors: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		6546	7529
HPRD ID		01659	03184
Ensembl ID		ENSG00000183023	ENSG00000166913
Uniprot IDs		P32418 Q4QQH3	P31946
PDB IDs			2BQ0 2C23 4DNK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Hippo Signaling Regulation Of Cardiac Muscle Hypertrophy Membrane Organization System Development Regulation Of Organelle Organization Cardiac Muscle Cell Action Potential Substantia Nigra Development Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Apoptotic Signaling Pathway Cellular Localization Multicellular Organismal Development Neural Nucleus Development Anatomical Structure Development Transport Regulation Of Potassium Ion Transport Protein Targeting Locomotion Negative Regulation Of Dephosphorylation Cellular Protein Localization Regulation Of Heart Rate Developmental Process Midbrain Development Action Potential Establishment Of Protein Localization Regulation Of Signaling Axonogenesis Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Intersection) ?