SLC8A1 and YWHAE

Number of citations of the paper that reports this interaction (PMID 16679322)
5

Data Source:
HPRD (in vitro)

		SLC8A1	YWHAE
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Z Disc T-tubule Sarcolemma	Mitochondrion Cytosol Kinesin Complex Focal Adhesion Membrane Axon Cytoplasmic Vesicle Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Metal Ion Binding	Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Histone Deacetylase Binding Ion Channel Binding Poly(A) RNA Binding Protein Heterodimerization Activity Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Embryonic Placenta Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Heart Morphogenesis Ion Transport Cellular Sodium Ion Homeostasis Muscle Contraction Blood Coagulation Post-embryonic Development Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Cellular Response To Reactive Oxygen Species Embryonic Heart Tube Development Response To Muscle Stretch Relaxation Of Smooth Muscle Muscle Fiber Development Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Cellular Response To Caffeine Sodium Ion Export Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Apoptotic Process Organelle Organization Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis	HSF1 activation Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane G2/M Transition Activation of BH3-only proteins Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Programmed Cell Death Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Assembly of the primary cilium Cellular response to heat stress Regulation of HSF1-mediated heat shock response Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Signaling by Hippo Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation NADE modulates death signalling Mitotic G2-G2/M phases
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		HIV-associated dementia ( 22628157) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) QT interval ( 22726844)
Protein-Protein Interactions		6 interactors: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	107 interactors: ABL1 ACD AKAP13 ANKHD1-EIF4EBP3 ARHGEF2 ARHGEF28 ATXN1 BAD BCR CALM1 CAP2 CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP95 CGNL1 CHAF1A COX2 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GTF2B HDAC4 HDAC5 HIVEP2 HSF1 IGF1R IL7R ING1 IRS1 IRS2 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KRT18 LRMP MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MDM4 MSL2 MST1R MYH10 NCOR2 NDEL1 NGFRAP1 PAPOLA PNLIP POT1 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 REM1 RGS3 RIN1 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SNCA SORBS2 SRC SSFA2 SYN2 TAF7 TAZ TBC1D3F TBP TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF839
Entrez ID		6546	7531
HPRD ID		01659	05457
Ensembl ID		ENSG00000183023	ENSG00000108953
Uniprot IDs		P32418 Q4QQH3	P62258
PDB IDs			2BR9 3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Hippo Signaling Regulation Of Cardiac Muscle Hypertrophy Membrane Organization System Development Regulation Of Organelle Organization Cardiac Muscle Cell Action Potential Substantia Nigra Development Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Apoptotic Signaling Pathway Cellular Localization Multicellular Organismal Development Neural Nucleus Development Anatomical Structure Development Transport Regulation Of Potassium Ion Transport Protein Targeting Locomotion Negative Regulation Of Dephosphorylation Cellular Protein Localization Regulation Of Heart Rate Developmental Process Midbrain Development Action Potential Establishment Of Protein Localization Regulation Of Signaling Axonogenesis Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation	Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor System Development Neurotrophin TRK Receptor Signaling Pathway Developmental Process Neurotrophin Signaling Pathway Negative Regulation Of Phosphorylation Response To Organic Substance Anatomical Structure Development Multicellular Organismal Development Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Programmed Cell Death Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Organonitrogen Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Intersection) ?