SLC8A1 and PPP3CB

Number of citations of the paper that reports this interaction (PMID 15557343)
10

Data Source:
HPRD (two hybrid, in vivo)

		SLC8A1	PPP3CB
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 1	protein phosphatase 3, catalytic subunit, beta isozyme
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Z Disc T-tubule Sarcolemma	Nucleoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Metal Ion Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity
	Biological Process	Embryonic Placenta Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Heart Morphogenesis Ion Transport Cellular Sodium Ion Homeostasis Muscle Contraction Blood Coagulation Post-embryonic Development Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Cellular Response To Reactive Oxygen Species Embryonic Heart Tube Development Response To Muscle Stretch Relaxation Of Smooth Muscle Muscle Fiber Development Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Cellular Response To Caffeine Sodium Ion Export Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export	Negative Regulation Of T Cell Mediated Cytotoxicity Protein Phosphorylation Protein Dephosphorylation Signal Transduction Heart Development Learning Memory Dephosphorylation Calcium Ion-dependent Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Social Behavior Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Positive Regulation Of NFAT Protein Import Into Nucleus
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		HIV-associated dementia ( 22628157) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) QT interval ( 22726844)
Protein-Protein Interactions		6 interactors: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	12 interactors: CABIN1 IRAK1 IRF2 JUN MARCH7 MYOZ2 MYOZ3 NFATC2 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		6546	5532
HPRD ID		01659	00235
Ensembl ID		ENSG00000183023	ENSG00000107758
Uniprot IDs		P32418 Q4QQH3	P16298
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Hippo Signaling Regulation Of Cardiac Muscle Hypertrophy Membrane Organization System Development Regulation Of Organelle Organization Cardiac Muscle Cell Action Potential Substantia Nigra Development Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Apoptotic Signaling Pathway Cellular Localization Multicellular Organismal Development Neural Nucleus Development Anatomical Structure Development Transport Regulation Of Potassium Ion Transport Protein Targeting Locomotion Negative Regulation Of Dephosphorylation Cellular Protein Localization Regulation Of Heart Rate Developmental Process Midbrain Development Action Potential Establishment Of Protein Localization Regulation Of Signaling Axonogenesis Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation	Calcium Ion Export Response To Wounding Innate Immune Response Response To Organonitrogen Compound Response To Stress Blood Coagulation Hemostasis Response To Purine-containing Compound Cellular Response To Organic Substance Cell Communication Sodium Ion Transmembrane Transport Regulation Of Body Fluid Levels Calcium Ion Import Calcium Ion Transmembrane Transport Wound Healing Immune Response Regulation Of Innate Immune Response Immune System Process Sodium Ion Transport Defense Response Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Response To Cytokine Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Toll-like Receptor TLR1:TLR2 Signaling Pathway Calcium Ion Transport Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Cellular Response To Potassium Ion Starvation MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Calcium Ion Import Into Cell Calcium Ion Export From Cell Leading Edge Cell Differentiation Sodium Ion Import Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Cytokine-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Immune Response-regulating Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Intersection) ?