SLC8A1 and AKAP6

		SLC8A1	AKAP6
Description		solute carrier family 8 member A1	A-kinase anchoring protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Axon Terminus Synapse Cell Periphery Postsynapse	Nucleus Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Membrane Sarcoplasmic Reticulum T-tubule Nuclear Membrane Protein-containing Complex Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Antiporter Activity Ankyrin Binding Transmembrane Transporter Binding Metal Ion Binding	Protein Binding Adenylate Cyclase Binding Protein Kinase A Regulatory Subunit Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Muscle Contraction Cell Communication Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Positive Regulation Of Bone Mineralization Cellular Response To Reactive Oxygen Species Sodium Ion Transmembrane Transport Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction	Action Potential Protein Targeting Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Positive Regulation Of Cell Growth Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Membrane Repolarization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs		alpha-Linolenic acid Icosapent Dronedarone Caldaret
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30598549 30158200) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte percentage of white cells ( 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 25035420 32439900 29127183) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QT interval ( 24952745 29213071 22726844) Refractive error ( 32231278) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 21079607) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Atrial fibrillation ( 29892015 30061737) Bipolar disorder ( 31043756) Body mass index ( 28448500 28892062 25673413 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Creatine kinase levels ( 29403010) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (environmentalism) ( 22566634) Fasting blood insulin (BMI interaction) ( 22581228) Femur bone mineral density x serum urate levels interaction ( 34046847) General cognitive ability ( 29844566) Glioma ( 28346443) HDL cholesterol levels ( 32203549) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Non-glioblastoma glioma ( 28346443) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Walking pace ( 33128006)
Interacting Genes		7 interacting genes: CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	11 interacting genes: CALM1 CDC5L DISC1 DTNBP1 NRIP1 PCNT PDE4D PPP2CA PRKAR2A RYR1 RYR2
Entrez ID		6546	9472
HPRD ID		01659	05257
Ensembl ID		ENSG00000183023	ENSG00000151320
Uniprot IDs		A0A994J4U7 A0A994J7E1 A0A994J7G2 E9PB98 P32418 Q4QQH3	B2RP22 Q13023
PDB IDs		8JP0 8SGI 8SGJ 8SGT
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Regulation Of Metal Ion Transport T-tubule Regulation Of Transport Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Membrane Repolarization Negative Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Intercalated Disc Protein Targeting Negative Regulation Of Calcium Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of System Process Positive Regulation Of Calcium Ion Transmembrane Transport Phosphoserine Residue Binding Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Cardiac Muscle Hypertrophy Caveola Regulation Of Potassium Ion Transport Positive Regulation Of Calcium Ion Transport Enzyme Binding Focal Adhesion Regulation Of Membrane Potential Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cellular Localization Intracellular Calcium Ion Homeostasis Regulation Of Heart Contraction Sodium Channel Regulator Activity Negative Regulation Of Protein Localization Calcium Ion Homeostasis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Cardiac Muscle Hypertrophy Protein Domain Specific Binding Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Regulation Of Muscle System Process	Calcium Channel Complex Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Caffeine Cellular Response To Purine-containing Compound Regulation Of Sequestering Of Calcium Ion Response To Caffeine Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sarcolemma Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Positive Regulation Of The Force Of Heart Contraction Intracellular Signal Transduction Transmembrane Transporter Binding Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Muscle Contraction Calcium-mediated Signaling Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Signal Transduction Junctional Sarcoplasmic Reticulum Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Calmodulin Binding Regulation Of Heart Contraction Cellular Response To Epinephrine Stimulus Muscle Contraction Calcium Ion Transport Into Cytosol Protein Kinase A Catalytic Subunit Binding Calcium Ion Homeostasis Detection Of Calcium Ion Regulation Of Calcium Ion Transport Response To Epinephrine Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Response To Alkaloid Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Muscle System Process Regulation Of Blood Circulation Muscle System Process
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