SLC8A1 and FXYD1

Number of citations: 49 (PubMedID 27247424)
Data Source: BioGRID (pull down)

		SLC8A1	FXYD1
Name		solute carrier family 8 member A1	FXYD domain containing ion transport regulator 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Axon Terminus Synapse Cell Periphery Postsynapse	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Apical Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Antiporter Activity Ankyrin Binding Transmembrane Transporter Binding Metal Ion Binding	Chloride Channel Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Ion Channel Regulator Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Muscle Contraction Cell Communication Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Positive Regulation Of Bone Mineralization Cellular Response To Reactive Oxygen Species Sodium Ion Transmembrane Transport Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Regulation Of Monoatomic Ion Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Sodium Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		alpha-Linolenic acid Icosapent Dronedarone Caldaret	None
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Asthma ( 27611488 ) Chronotype ( 30696823 ) Diastolic blood pressure ( 28135244 ) Early spontaneous preterm birth ( 31194736 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Estimated glomerular filtration rate ( 31451708 31152163 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting glucose ( 34059833 ) Fractional exhaled nitric oxide levels ( 25431337 ) Fractures ( 30598549 30158200 ) Hand grip strength ( 29691431 29313844 ) Heel bone mineral density ( 30598549 28869591 ) HIV-associated dementia ( 22628157 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) Lymphocyte percentage of white cells ( 32888494 ) Mitochondrial DNA levels ( 25240745 ) Neutrophil percentage of white cells ( 32888494 ) Obesity (early onset extreme) ( 23563609 ) Obesity-related traits ( 23251661 ) PR interval ( 25035420 32439900 29127183 ) Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) QT interval ( 24952745 29213071 22726844 ) Refractive error ( 32231278 ) Serum immune biomarker levels ( 32066700 ) Systolic blood pressure ( 30578418 ) Tea consumption ( 31046077 ) Total body bone mineral density ( 29304378 ) TPE interval (resting) ( 32386560 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: AKAP6	None recorded
Interacting Genes		7 interacting genes: CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ
Entrez ID		6546	5348
HPRD ID		01659	03837
Ensembl ID		ENSG00000183023	ENSG00000266964
Uniprot IDs		A0A994J4U7 A0A994J7E1 A0A994J7G2 E9PB98 P32418 Q4QQH3	O00168
PDB IDs		8JP0 8SGI 8SGJ 8SGT	2JO1
GO Terms Enriched among Interactors		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Regulation Of Metal Ion Transport T-tubule Regulation Of Transport Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Membrane Repolarization Negative Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Intercalated Disc Protein Targeting Negative Regulation Of Calcium Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of System Process Positive Regulation Of Calcium Ion Transmembrane Transport Phosphoserine Residue Binding Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Cardiac Muscle Hypertrophy Caveola Regulation Of Potassium Ion Transport Positive Regulation Of Calcium Ion Transport Enzyme Binding Focal Adhesion Regulation Of Membrane Potential Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cellular Localization Intracellular Calcium Ion Homeostasis Regulation Of Heart Contraction Sodium Channel Regulator Activity Negative Regulation Of Protein Localization Calcium Ion Homeostasis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Cardiac Muscle Hypertrophy Protein Domain Specific Binding Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Regulation Of Muscle System Process	Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Regulation Of Striated Muscle Contraction Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Muscle System Process Intracellular Potassium Ion Homeostasis Relaxation Of Muscle Intracellular Sodium Ion Homeostasis Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Monoatomic Cation Homeostasis Sodium Ion Homeostasis Potassium Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Calcium-mediated Signaling T-tubule Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Export Across Plasma Membrane Intracellular Signal Transduction Regulation Of System Process P-type Sodium:potassium-exchanging Transporter Activity Regulation Of Sodium Ion Transport Cellular Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport Extracellular Exosome Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Inorganic Cation Import Across Plasma Membrane Sarcolemma Sperm Flagellum Chemical Homeostasis Intracellular Signaling Cassette Sodium Ion Transmembrane Transport Regulation Of Transport Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Import Across Plasma Membrane Membrane Repolarization During Action Potential