SLC8A1 and TRPC3

Number of citations of the paper that reports this interaction (PMID 14736881)
32

Data Source:
HPRD (in vitro, in vivo)

		SLC8A1	TRPC3
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 1	transient receptor potential cation channel, subfamily C, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Z Disc T-tubule Sarcolemma	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Metal Ion Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Embryonic Placenta Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Heart Morphogenesis Ion Transport Cellular Sodium Ion Homeostasis Muscle Contraction Blood Coagulation Post-embryonic Development Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Cellular Response To Reactive Oxygen Species Embryonic Heart Tube Development Response To Muscle Stretch Relaxation Of Smooth Muscle Muscle Fiber Development Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Cellular Response To Caffeine Sodium Ion Export Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		HIV-associated dementia ( 22628157) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) QT interval ( 22726844)
Protein-Protein Interactions		6 interactors: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		6546	7222
HPRD ID		01659	15999
Ensembl ID		ENSG00000183023	ENSG00000138741
Uniprot IDs		P32418 Q4QQH3	J3QTB0 Q13507
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Hippo Signaling Regulation Of Cardiac Muscle Hypertrophy Membrane Organization System Development Regulation Of Organelle Organization Cardiac Muscle Cell Action Potential Substantia Nigra Development Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Apoptotic Signaling Pathway Cellular Localization Multicellular Organismal Development Neural Nucleus Development Anatomical Structure Development Transport Regulation Of Potassium Ion Transport Protein Targeting Locomotion Negative Regulation Of Dephosphorylation Cellular Protein Localization Regulation Of Heart Rate Developmental Process Midbrain Development Action Potential Establishment Of Protein Localization Regulation Of Signaling Axonogenesis Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?