SLC8A1 and CAV3

Number of citations of the paper that reports this interaction (PMID 11821059)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SLC8A1	CAV3
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 1	caveolin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Z Disc T-tubule Sarcolemma	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Z Disc T-tubule Neuromuscular Junction Vesicle Sarcolemma Membrane Raft
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Metal Ion Binding	Calcium Channel Regulator Activity Protein Binding Protein C-terminus Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Protein Complex Binding Protein Complex Scaffold Alpha-tubulin Binding Ion Channel Binding Nitric-oxide Synthase Binding Connexin Binding
	Biological Process	Embryonic Placenta Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Heart Morphogenesis Ion Transport Cellular Sodium Ion Homeostasis Muscle Contraction Blood Coagulation Post-embryonic Development Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Cellular Response To Reactive Oxygen Species Embryonic Heart Tube Development Response To Muscle Stretch Relaxation Of Smooth Muscle Muscle Fiber Development Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Cellular Response To Caffeine Sodium Ion Export Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export	Plasma Membrane Repair Regulation Of Heart Rate Negative Regulation Of Protein Kinase Activity Triglyceride Metabolic Process Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Cell Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Muscle Cell Cellular Homeostasis Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nerve Growth Factor Receptor Activity Nucleus Localization Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		HIV-associated dementia ( 22628157) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) QT interval ( 22726844)
Protein-Protein Interactions		6 interactors: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	15 interactors: DAG1 DYSF EGFR GNAS INSR JPH2 NOS1 PCBP1 PDGFRA PDGFRB PFKM PTGES3 SENP1 SLC22A11 SLC8A1
Entrez ID		6546	859
HPRD ID		01659	03154
Ensembl ID		ENSG00000183023	ENSG00000182533
Uniprot IDs		P32418 Q4QQH3	P56539
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Hippo Signaling Regulation Of Cardiac Muscle Hypertrophy Membrane Organization System Development Regulation Of Organelle Organization Cardiac Muscle Cell Action Potential Substantia Nigra Development Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Apoptotic Signaling Pathway Cellular Localization Multicellular Organismal Development Neural Nucleus Development Anatomical Structure Development Transport Regulation Of Potassium Ion Transport Protein Targeting Locomotion Negative Regulation Of Dephosphorylation Cellular Protein Localization Regulation Of Heart Rate Developmental Process Midbrain Development Action Potential Establishment Of Protein Localization Regulation Of Signaling Axonogenesis Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Regulation Of Nerve Growth Factor Receptor Activity Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation	Homeostatic Process Chemical Homeostasis Wound Healing Organ Morphogenesis Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of The Force Of Heart Contraction Response To Wounding Positive Regulation Of Transport Exocrine System Development Regulation Of Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Response To Organonitrogen Compound Glomerular Capillary Formation Cellular Response To Organonitrogen Compound Protein Autophosphorylation Cardiac Muscle Cell Development Positive Regulation Of DNA Replication Striated Muscle Cell Differentiation Metanephric Glomerulus Vasculature Development Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Metanephric Glomerulus Development Glomerulus Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Interaction With Host Anatomical Structure Morphogenesis Tissue Development Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Cellular Component Movement Response To Organic Substance Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated itga2b marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt tmem207 transcriptomes vegfr	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Intersection) ?