SLC8A1 and CAV3

Number of citations of the paper that reports this interaction (PubMedID 11821059)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SLC8A1	CAV3
Description		solute carrier family 8 member A1	caveolin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Axon Terminus Synapse Cell Periphery Postsynapse	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft
	Molecular Function	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Antiporter Activity Ankyrin Binding Transmembrane Transporter Binding Metal Ion Binding	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Muscle Contraction Cell Communication Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Positive Regulation Of Bone Mineralization Cellular Response To Reactive Oxygen Species Sodium Ion Transmembrane Transport Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		alpha-Linolenic acid Icosapent Dronedarone Caldaret
Diseases			Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30598549 30158200) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte percentage of white cells ( 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 25035420 32439900 29127183) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QT interval ( 24952745 29213071 22726844) Refractive error ( 32231278) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172)	Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)
Interacting Genes		7 interacting genes: CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA
Entrez ID		6546	859
HPRD ID		01659	03154
Ensembl ID		ENSG00000183023	ENSG00000182533
Uniprot IDs		A0A994J4U7 A0A994J7E1 A0A994J7G2 E9PB98 P32418 Q4QQH3	P56539
PDB IDs		8JP0 8SGI 8SGJ 8SGT
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Regulation Of Metal Ion Transport T-tubule Regulation Of Transport Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Membrane Repolarization Negative Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Intercalated Disc Protein Targeting Negative Regulation Of Calcium Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of System Process Positive Regulation Of Calcium Ion Transmembrane Transport Phosphoserine Residue Binding Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Cardiac Muscle Hypertrophy Caveola Regulation Of Potassium Ion Transport Positive Regulation Of Calcium Ion Transport Enzyme Binding Focal Adhesion Regulation Of Membrane Potential Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cellular Localization Intracellular Calcium Ion Homeostasis Regulation Of Heart Contraction Sodium Channel Regulator Activity Negative Regulation Of Protein Localization Calcium Ion Homeostasis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Cardiac Muscle Hypertrophy Protein Domain Specific Binding Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Regulation Of Muscle System Process	Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction
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