BMP6 and SMAD5

Number of citations of the paper that reports this interaction (PubMedID 10504300)
0

Data Source:
HPRD (in vivo)

		BMP6	SMAD5
Description		bone morphogenetic protein 6	SMAD family member 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Enzyme Activator Complex	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Intracellular Iron Ion Homeostasis Inflammatory Response Immune Response Heart Development Positive Regulation Of Cell Population Proliferation Tissue Development Response To Iron Ion Positive Regulation Of Gene Expression Response To Activity Cell Differentiation Neuron Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Developmental Process Cartilage Development Response To Glucocorticoid Bone Development Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 20881960 31562340 18391951 28552196 25429064 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 30578418 27841878) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) Spondylosis ( 33332786) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 CRIPTO NCOA3 SMAD5 SOSTDC1	47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID		654	4090
HPRD ID		00211	04381
Ensembl ID		ENSG00000153162	ENSG00000113658
Uniprot IDs		B4DUF7 P22004 Q4VBA3	Q68DB7 Q99717
PDB IDs		2QCW 2R52 2R53 6OMO	6FZS 6TCE
Enriched GO Terms of Interacting Partners?		BMP Receptor Activity BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Binding Positive Regulation Of Osteoblast Differentiation Cellular Response To BMP Stimulus Enzyme-linked Receptor Protein Signaling Pathway Pattern Specification Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Regulation Of Bone Mineralization Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Regulation Of Ossification Mitral Valve Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Developmental Process Positive Regulation Of Developmental Process Atrioventricular Valve Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Signal Transduction Animal Organ Development Anatomical Structure Morphogenesis Cartilage Development Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Activin Receptor Activity, Type II Developmental Process Ventricular Septum Morphogenesis Tissue Development Mullerian Duct Regression Tricuspid Valve Morphogenesis Anterior/posterior Pattern Specification Growth Factor Binding Protein Serine/threonine Kinase Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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