BMP6 and BMPER

Number of citations of the paper that reports this interaction (PubMedID 12897139)
73

Data Source:
HPRD (in vivo)

		BMP6	BMPER
Description		bone morphogenetic protein 6	BMP binding endothelial regulator
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Enzyme Activator Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	Extracellular Matrix Structural Constituent
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Intracellular Iron Ion Homeostasis Inflammatory Response Immune Response Heart Development Positive Regulation Of Cell Population Proliferation Tissue Development Response To Iron Ion Positive Regulation Of Gene Expression Response To Activity Cell Differentiation Neuron Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Developmental Process Cartilage Development Response To Glucocorticoid Bone Development Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Blood Vessel Development Ureteric Bud Development Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Endothelial Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Protein Localization Tube Development Endothelial Cell Activation Regulation Of Angiogenesis System Development Inner Ear Development Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 20881960 31562340 18391951 28552196 25429064 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 30578418 27841878) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) Spondylosis ( 33332786) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Alzheimer's disease ( 24770881) Asthma ( 29273806) Corneal astigmatism ( 29422769) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Longevity ( 33657282) Post bronchodilator FEV1 ( 26634245) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 CRIPTO NCOA3 SMAD5 SOSTDC1	3 interacting genes: BMP2 BMP4 BMP6
Entrez ID		654	168667
HPRD ID		00211	16368
Ensembl ID		ENSG00000153162	ENSG00000164619
Uniprot IDs		B4DUF7 P22004 Q4VBA3	A0A090N7U6 A0A3B3ITW7 Q8N8U9
PDB IDs		2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?		BMP Receptor Activity BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Binding Positive Regulation Of Osteoblast Differentiation Cellular Response To BMP Stimulus Enzyme-linked Receptor Protein Signaling Pathway Pattern Specification Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Regulation Of Bone Mineralization Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Regulation Of Ossification Mitral Valve Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Developmental Process Positive Regulation Of Developmental Process Atrioventricular Valve Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Signal Transduction Animal Organ Development Anatomical Structure Morphogenesis Cartilage Development Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Activin Receptor Activity, Type II Developmental Process Ventricular Septum Morphogenesis Tissue Development Mullerian Duct Regression Tricuspid Valve Morphogenesis Anterior/posterior Pattern Specification Growth Factor Binding Protein Serine/threonine Kinase Activity	BMP Receptor Binding Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Regulation Of SMAD Protein Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Bone Development Positive Regulation Of Epithelial Cell Differentiation Enzyme Activator Complex Regulation Of Bone Mineralization BMP Signaling Pathway Cardiac Jelly Development Positive Regulation Of Neuron Differentiation Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Telencephalon Regionalization Regulation Of Ossification Osteoblast Differentiation Ossification Ameloblast Differentiation Positive Regulation Of Odontoblast Differentiation Regulation Of Aldosterone Biosynthetic Process Heart Induction Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Osteoblast Differentiation Growth Factor Activity Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Heart Morphogenesis Regulation Of Epithelial Cell Differentiation Regulation Of Odontoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Lung Vasculature Development Skeletal System Development Co-receptor Binding Regulation Of Neuron Differentiation Type B Pancreatic Cell Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Endothelial Cell Differentiation Cytokine Activity Regulation Of Odontogenesis Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Cardiac Muscle Cell Differentiation Heart Development Cellular Response To Growth Factor Stimulus Regulation Of Ketone Biosynthetic Process
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