BMP6 and BMPR1A

Number of citations of the paper that reports this interaction (PubMedID 11401330)
0

Data Source:
HPRD (in vivo)

		BMP6	BMPR1A
Description		bone morphogenetic protein 6	bone morphogenetic protein receptor type 1A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Enzyme Activator Complex	Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Intracellular Iron Ion Homeostasis Inflammatory Response Immune Response Heart Development Positive Regulation Of Cell Population Proliferation Tissue Development Response To Iron Ion Positive Regulation Of Gene Expression Response To Activity Cell Differentiation Neuron Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Developmental Process Cartilage Development Response To Glucocorticoid Bone Development Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Intracellular Iron Ion Homeostasis Immune Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Ectoderm Development Nervous System Development Endoderm Development Heart Development Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Central Nervous System Neuron Differentiation Pituitary Gland Development Neural Plate Mediolateral Regionalization Cell Differentiation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Population Maintenance Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Neural Plate Pattern Specification Heart Formation Atrioventricular Node Cell Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Senescence
Pathways			Signaling by BMP
Drugs			Dibotermin alfa
Diseases			Juvenile polyposis syndrome Hereditary mixed polyposis syndrome
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 20881960 31562340 18391951 28552196 25429064 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 30578418 27841878) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) Spondylosis ( 33332786) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 CRIPTO NCOA3 SMAD5 SOSTDC1	45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CRIPTO CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189
Entrez ID		654	657
HPRD ID		00211	03192
Ensembl ID		ENSG00000153162	ENSG00000107779
Uniprot IDs		B4DUF7 P22004 Q4VBA3	P36894
PDB IDs		2QCW 2R52 2R53 6OMO	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		BMP Receptor Activity BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Binding Positive Regulation Of Osteoblast Differentiation Cellular Response To BMP Stimulus Enzyme-linked Receptor Protein Signaling Pathway Pattern Specification Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Regulation Of Bone Mineralization Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Regulation Of Ossification Mitral Valve Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Developmental Process Positive Regulation Of Developmental Process Atrioventricular Valve Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Signal Transduction Animal Organ Development Anatomical Structure Morphogenesis Cartilage Development Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Activin Receptor Activity, Type II Developmental Process Ventricular Septum Morphogenesis Tissue Development Mullerian Duct Regression Tricuspid Valve Morphogenesis Anterior/posterior Pattern Specification Growth Factor Binding Protein Serine/threonine Kinase Activity	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Signal Transduction Cellular Response To BMP Stimulus Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Cartilage Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development BMP Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Ossification Anatomical Structure Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Signaling Regulation Of Cell Communication Regulation Of Ossification Regulation Of Bone Mineralization Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Cytokine Activity Regulation Of Primary Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Morphogenesis Response To Growth Factor Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Endocardial Cushion Formation Signal Transduction Regulation Of RNA Metabolic Process Heart Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?