BMP6 and BMPR1A

Number of citations of the paper that reports this interaction (PMID 10504300)
42

Data Source:
HPRD (in vivo)

		BMP6	BMPR1A
Gene Name		bone morphogenetic protein 6	bone morphogenetic protein receptor, type IA
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane-bounded Vesicle	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Response To Iron Ion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Cartilage Development Response To Glucocorticoid SMAD Protein Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Aldosterone Secretion	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666)
Protein-Protein Interactions		9 interactors: ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1	23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11
Entrez ID		654	657
HPRD ID		00211	03192
Ensembl ID		ENSG00000153162
Uniprot IDs		B4DUF7 P22004 Q4VBA3	P36894
PDB IDs		2QCW 2R52 2R53	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Tissue Development Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development Regulation Of Ossification Pattern Specification Process Organ Development Regulation Of Bone Mineralization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Skeletal System Development Sex Differentiation Tube Development Anatomical Structure Morphogenesis Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Cell Differentiation System Development Regulation Of Cell Differentiation Regulation Of Signal Transduction Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Epithelium Development Regulation Of Signaling Anatomical Structure Development Mullerian Duct Regression Developmental Process Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Organ Morphogenesis Anatomical Structure Regression Mesoderm Development Embryo Development Cellular Response To BMP Stimulus Single Organism Reproductive Process Male Sex Differentiation Gastrulation Positive Regulation Of Signal Transduction Limb Development Reproductive Process Protein Phosphorylation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development
Tagcloud ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Intersection) ?