BMP6 and CHRDL2

Number of citations of the paper that reports this interaction (PubMedID 14660436)
0

Data Source:
HPRD (in vivo)

		BMP6	CHRDL2
Description		bone morphogenetic protein 6	chordin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Enzyme Activator Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	Protein Binding BMP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Intracellular Iron Ion Homeostasis Inflammatory Response Immune Response Heart Development Positive Regulation Of Cell Population Proliferation Tissue Development Response To Iron Ion Positive Regulation Of Gene Expression Response To Activity Cell Differentiation Neuron Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Developmental Process Cartilage Development Response To Glucocorticoid Bone Development Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 20881960 31562340 18391951 28552196 25429064 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 30578418 27841878) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) Spondylosis ( 33332786) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 CRIPTO NCOA3 SMAD5 SOSTDC1	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		654	25884
HPRD ID		00211	09881
Ensembl ID		ENSG00000153162	ENSG00000054938
Uniprot IDs		B4DUF7 P22004 Q4VBA3	Q6WN34
PDB IDs		2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?		BMP Receptor Activity BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Binding Positive Regulation Of Osteoblast Differentiation Cellular Response To BMP Stimulus Enzyme-linked Receptor Protein Signaling Pathway Pattern Specification Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Regulation Of Bone Mineralization Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Regulation Of Ossification Mitral Valve Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Developmental Process Positive Regulation Of Developmental Process Atrioventricular Valve Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Signal Transduction Animal Organ Development Anatomical Structure Morphogenesis Cartilage Development Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Activin Receptor Activity, Type II Developmental Process Ventricular Septum Morphogenesis Tissue Development Mullerian Duct Regression Tricuspid Valve Morphogenesis Anterior/posterior Pattern Specification Growth Factor Binding Protein Serine/threonine Kinase Activity	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process
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