BMP6 and CHRDL2

Number of citations of the paper that reports this interaction (PMID 14660436)
14

Data Source:
HPRD (in vivo)

		BMP6	CHRDL2
Gene Name		bone morphogenetic protein 6	chordin-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane-bounded Vesicle	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Response To Iron Ion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Cartilage Development Response To Glucocorticoid SMAD Protein Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Aldosterone Secretion	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway Cartilage Development
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666)
Protein-Protein Interactions		9 interactors: ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1	7 interactors: BMP2 BMP4 BMP5 BMP6 BMP7 GDF5 INHBA
Entrez ID		654	25884
HPRD ID		00211	09881
Ensembl ID		ENSG00000153162	ENSG00000054938
Uniprot IDs		B4DUF7 P22004 Q4VBA3	Q6WN34
PDB IDs		2QCW 2R52 2R53
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Tissue Development Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development Regulation Of Ossification Pattern Specification Process Organ Development Regulation Of Bone Mineralization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Skeletal System Development Sex Differentiation Tube Development Anatomical Structure Morphogenesis Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Cell Differentiation System Development Regulation Of Cell Differentiation Regulation Of Signal Transduction Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Epithelium Development Regulation Of Signaling Anatomical Structure Development Mullerian Duct Regression Developmental Process Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Organ Morphogenesis Anatomical Structure Regression Mesoderm Development Embryo Development Cellular Response To BMP Stimulus Single Organism Reproductive Process Male Sex Differentiation Gastrulation Positive Regulation Of Signal Transduction Limb Development Reproductive Process Protein Phosphorylation	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Cartilage Development Connective Tissue Development Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Neurogenesis Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Regulation Of Protein Phosphorylation Glandular Epithelial Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Proliferation Involved In Kidney Development Ossification Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Death Regulation Of Cell Differentiation Regulation Of Cartilage Development Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Ossification Tissue Development Type B Pancreatic Cell Development Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?